Twenty-two microRNAs are found to be amplified or deleted in hepatocellular carcinoma (HCC). miR-151 is encoded by an intron in the focal adhesion kinase FAK-1 gene, with which it is co-transcribed, and increases HCC cell migration in vitro and invasion in vivo by directly targeting RhoGDIA. miR-151 amplification correlates with HCC metastasis.
- Jie Ding
- Shenglin Huang
- Xianghuo He
