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Showing 1–9 of 9 results
Advanced filters: Author: Dafydd R Owen Clear advanced filters

  • Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap article sets out how that will be achieved.

    • Aled M. Edwards
    • Dafydd R. Owen
    • Suzanne Ackloo
    Reviews
    Nature Reviews Chemistry
    Volume: 9, P: 634-645

  • Through simultaneous binding to more than one site in a single protein, multivalent small molecules can achieve huge increases in potency. This 'avidity effect' has been demonstrated in BET bromodomain-containing proteins with bivalent probes that represent some of the most potent BET inhibitors to date.

    • Dafydd Owen
    News & Views
    Nature Chemical Biology
    Volume: 12, P: 991-992

  • Owens et al. reported PFI-7, a selective and potent antagonist of GID4 of the CTLH E3 ligase complex, which enables identification of human GID4 targets. This study provides valuable insights into GID4 functions and a powerful tool for advancing new targeted protein degradation strategies.

    • Dominic D. G. Owens
    • Matthew E. R. Maitland
    • Cheryl H. Arrowsmith
    Research
    Nature Chemical Biology
    Volume: 20, P: 1164-1175

  • VCSEL-based photonic Spiking Neural Networks (p-SNNs) have achieved very good performance on classification tasks, however the lack of internal memory has prevented their use in predictive tasks. Here the authors introduce a p-SNN with added memory capacity and show that it can predict a chaotic time series with excellent accuracy

    • Dafydd Owen-Newns
    • Lina Jaurigue
    • Antonio Hurtado
    ResearchOpen Access
    Communications Physics
    Volume: 8, P: 1-9

  • Artificial intelligence is greatly accelerating research in drug discovery, but its development is still hindered by the lack of available data. Here the authors present data management and data science recommendations to help reach AI’s potential in the field.

    • Kristina Edfeldt
    • Aled M. Edwards
    • Matthieu Schapira
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

    • Cheryl H Arrowsmith
    • James E Audia
    • William J Zuercher
    Comments & Opinion
    Nature Chemical Biology
    Volume: 11, P: 536-541