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Showing 1–8 of 8 results
Advanced filters: Author: Dahu Li Clear advanced filters

  • Cancer cells often develop resistance to radiotherapy but the molecular mechanisms responsible remain unclear. Here the authors show that miR-205 promotes radiosensitivity and is downregulated in radioresistant subpopulations of breast cancer cells, and that its loss is associated with poor distant relapse-free survival in breast cancer patients.

    • Peijing Zhang
    • Li Wang
    • Li Ma
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • The stability of the PTEN tumour suppressor protein is regulated by polyubiquitylation. Ma and colleagues identify USP13 as an enzyme reversing polyubiquitylation of PTEN, leading to PTEN stabilization and tumour suppression.

    • Jinsong Zhang
    • Peijing Zhang
    • Li Ma
    Research
    Nature Cell Biology
    Volume: 15, P: 1486-1494

  • The authors identify LIFR as a breast cancer metastasis suppressor by showing how its loss promotes metastasis without substantial effect on primary tumor growth. This function of LIFR involves promoting the membrane localization of Scribble and enabling the cytoplasmic sequestration of Hippo pathway transducers, thus involving this signaling pathway in metastasis control. LIFR loss is also observed in human breast tumors, where it correlates with poor prognosis.

    • Dahu Chen
    • Yutong Sun
    • Li Ma
    Research
    Nature Medicine
    Volume: 18, P: 1511-1517

  • Zhang and colleagues have developed a new targeted delivery system for RNA interference–based bone anabolic therapy. Using dioleoyl trimethylammonium propane (DOTAP)-based cationic liposomes attached to six repetitive sequences of aspartate, serine, serine (AspSerSer)6, the system provided selective enrichment of the encapsulated osteogenic siRNA in osteogenic lineage cells at the bone formation surface and the subsequent depletion of the target gene, encoding the bone formation inhibitor casein kinase-2 interacting protein-1 (PLEKHO1, also known as CKIP-1), leading to the promotion of bone formation in healthy and osteoporotic rats.

    • Ge Zhang
    • Baosheng Guo
    • Ling Qin
    Research
    Nature Medicine
    Volume: 18, P: 307-314