Graphical representation of the regulation of c-myc by the cholesterol-RORα/γ axis. Cholesterol in CRC cells is derived from de novo synthesis and exogenous uptake of LDL. Cholesterol and its derivatives inhibit the transcriptional activity of RORα/γ on NEDD4, which results in the stabilization of the c-myc protein. The combination of atorvastatin and SR1078 has a synergistic inhibitory effect on CRC cells.
- Ying-Nan Wang
- Dan-Yun Ruan
- Zhao-Lei Zeng
