The as-prepared multifunctional upconversion–nanoparticles–trismethylpyridylporphyrin–fullerene nanocomposite (UCNP–PEG–FA/PC70) nanocomposite not only could utilize UCNPs to convert NIR light to ultraviolet–visible one to activate PC70 producing 1O2 for killing cancer cells under low-oxygen conditions, but also could act as a theranostic agent for trimodal fluorescence/upconversion luminescence/magnetic resonance imaging-guided photodynamic therapy (PDT). The synthesized UCNP–PEG–FA/PC70 would pave the way of efficient PDT, namely, limited penetration depth and oxygen-deficient microenvironment, which hinder the efficiency of PDT.
- Mirong Guan
- Hao Dong
- Chunying Shu
