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Showing 1–13 of 13 results
Advanced filters: Author: Daishun Ling Clear advanced filters

  • Reactive oxygen species management is a practical strategy that can reduce the risk of chemotherapy-induced acute kidney injury, but at the cost of chemotherapeutic efficacy. Here the authors report catalytic activity tunable ceria nanoparticles as context-dependent reactive oxygen species scavengers, which can prevent chemotherapy-induced acute kidney injury without interfering with chemotherapeutic agents.

    • Qinjie Weng
    • Heng Sun
    • Daishun Ling
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Detection of a wide range of tumours remains a challenge in cancer diagnostics. By exploiting changes in the tumour microenvironment, a pH-responsive polymeric nanomaterial enables ultrasensitive tumour-specific imaging in many types of cancer.

    • Daishun Ling
    • Michael J. Hackett
    • Taeghwan Hyeon
    News & Views
    Nature Materials
    Volume: 13, P: 122-124

  • A metabolic-enzyme-like nanocatalyst is reported, dubbed ‘artificial metabzyme’. Tumour cells can be metabolically reprogrammed to autonomously modulate and interact with immune cells, facilitating tumour-cell-specific metabolic therapy.

    • Xi Hu
    • Bo Zhang
    • Daishun Ling
    Research
    Nature Nanotechnology
    Volume: 19, P: 1712-1722

  • Direct modulation of protein by artificial catalysts as enzyme mimetics remains hindered by the lack of highly efficient catalytic centers. Here, the authors present the development of artificial protein modulators (APROMs) with protein phosphatase-like characteristics, catalytically reprogram the biological function of α-synuclein.

    • Peihua Lin
    • Bo Zhang
    • Daishun Ling
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • In vivo manipulation of the dynamics of nanoparticles’ is essential for disease-specific imaging and therapy, but tends to involve complex design processes. Here, the authors report a strategy for manipulating the assembly of nanoparticles in vivo through a self-catalysis-instructed dimerization of tyrosine, offering convenient fabrication, high reaction specificity and biocompatibility.

    • Mengmeng Xia
    • Qiyue Wang
    • Daishun Ling
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • One of the mechanisms underlying platinum (Pt) resistance is the spontaneous nucleotide-excision repair of cancer cells. Here, nuclease-mimetic Pt nanozymes are targeted to the cancer cell nucleus and induce concurrent DNA platination and oxidative cleavage to overcome Pt resistance.

    • Fangyuan Li
    • Heng Sun
    • Daishun Ling
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Ultra-high-field (UHF) magnetic resonance imaging (MRI) has potential for imaging disease including cancer metastasis. Here, the authors develop an ultra-sensitive antiferromagnetic nanoparticle probe with a small magnetisation for use in UHF MRI and demonstrate the ability to detect small primary tumours and micrometastases in mice.

    • Zeyu Liang
    • Qiyue Wang
    • Daishun Ling
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Extracellular potassium levels in the brain can be correlated to neural activity. A selective potassium sensor, in which cations other than potassium are shielded by a membrane, can measure potassium concentration changes in the brain of freely moving mice undergoing epileptic seizures.

    • Jianan Liu
    • Fangyuan Li
    • Daishun Ling
    Research
    Nature Nanotechnology
    Volume: 15, P: 321-330

  • Current endoscopes are limited to detection or treatment of colon cancers and growths, or resolution is too low for clinical application. Here the authors present a multimodal endoscope with theranostic nanoparticles that integrates fluorescence-based mapping, electrical impedance, pH and temperature monitoring, RF ablation and localized phototherapy or chemotherapy.

    • Hyunjae Lee
    • Youngsik Lee
    • Dae-Hyeong Kim
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • The role of surface ligands in tuning the optoelectronic properties, controlling the stability and determining the performance in applications of colloidal nanocrystals is discussed in this Review.

    • Michael A. Boles
    • Daishun Ling
    • Dmitri V. Talapin
    Reviews
    Nature Materials
    Volume: 15, P: 141-153