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Structural basis of BAK activation in mitochondrial apoptosis initiation

The authors show that the mechanism of BAK activation in mitochondrial apoptosis involves cooperation between direct activation by BH3-only protein BID and BAK autoactivation, providing a unifying basis for BAK triggering by BH3 ligands.

Geetika Singh
Cristina D. Guibao
Tudor Moldoveanu
ResearchOpen Access11 Jan 2022
Nature Communications

Volume: 13, P: 1-15
Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration

Quail and colleagues demonstrate that neutrophil-derived ROS and extracellular traps (NETs) mediate breast cancer metastasis to the lungs by altering endothelial junctional adhesions, thus favoring vascular permeability and transendothelial migration of cancer cells.

Sheri A. C. McDowell
Robin B. E. Luo
Daniela F. Quail
Research03 May 2021
Nature Cancer

Volume: 2, P: 545-562
Multi-omic analysis reveals significantly mutated genes and DDX3X as a sex-specific tumor suppressor in cutaneous melanoma

Alkallas et al. uncover new significantly mutated genes in a large cohort of cutaneous melanoma, including the RNA helicase DDX3X, through integrated analysis of genomic, transcriptomic and DNA methylation data.

Rached Alkallas
Mathieu Lajoie
Ian R. Watson
Research22 Jun 2020
Nature Cancer

Volume: 1, P: 635-652