Fear-extinction learning increases the expression of the brain-specific microRNA miR-128b. The authors find that this increase in miR-128b expression disrupts the stability of plasticity-related target genes and directly regulates fear-extinction memory. Increased miR-128b activity could facilitate the transition from retrieval of the original fear memory to the formation of a new fear-extinction memory.
- Quan Lin
- Wei Wei
- Timothy W Bredy
