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Showing 1–4 of 4 results
Advanced filters: Author: Danica Galonić Fujimori Clear advanced filters

  • By converting prolyl to 4-hydroxyprolyl residues, prolyl hydroxylases induce a conformational bias into proteins. This conformational preference is a result of a stereoelectronic gauche effect and is crucial for protein-protein recognition in oxygen sensing.

    • Danica Galonić Fujimori
    News & Views
    Nature Chemical Biology
    Volume: 5, P: 202-203

  • Histone lysine methylation plays crucial roles in controlling gene expression. Here the authors demonstrate that the activity of the histone lysine demethylase KDM5A is regulated through a feedback mechanism involving communication between the histone tail-binding and catalytic domains.

    • Idelisse Ortiz Torres
    • Kristopher M. Kuchenbecker
    • Danica Galonić Fujimori
    Research
    Nature Communications
    Volume: 6, P: 1-10

  • The authors determine the cryo-EM structures of prokaryotic ribosomes with the oxazolidinone antibiotics linezolid and radezolid bound to the peptidyl transferase center with an adjacent growing nascent peptide chain, providing an explanation for their context-specific action.

    • Kaitlyn Tsai
    • Vanja Stojković
    • Danica Galonić Fujimori
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 162-171

  • The demethylase activity of KDM5A is allosterically enhanced by binding of histone H3 to its PHD1 reader domain, through an unknown mechanism. Here the authors show that the PHD1 domain drives ligand-induced allosteric stimulation by stabilizing the binding of substrate to the catalytic domain.

    • James E. Longbotham
    • Cynthia M. Chio
    • Danica Galonić Fujimori
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12