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Showing 1–8 of 8 results
Advanced filters: Author: Daniel A. Muruve Clear advanced filters

  • Alum has long been used as a vaccine adjuvant, yet the mechanisms by which it increases antigen-specific immune responses remain unclear. Flach et al. now report that alum interacts with lipids in the plasma membrane of dendritic cells, resulting in nonphagocytic uptake of antigen and increased association with CD4+ T cells. These results suggest that, at least for dendritic cells, lipids rather than proteins may sense alum and trigger downstream signaling events that lead to enhanced T cell responses.

    • Tracy L Flach
    • Gilbert Ng
    • Yan Shi
    Research
    Nature Medicine
    Volume: 17, P: 479-487

  • Since their discovery in 2002, inflammasomes have been shown to be crucial mediators of caspase 1 activation, interleukin-1β and interleukin-18 release, and pyroptotic cell death. This Review describes our current understanding of the functions of different inflammasomes in the CNS and their roles in neurological diseases.

    • John G. Walsh
    • Daniel A. Muruve
    • Christopher Power
    Reviews
    Nature Reviews Neuroscience
    Volume: 15, P: 84-97

  • Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Here, the authors provide an overview of the basic biology of gasdermins and pyroptosis with a focus on the mechanisms by which these proteins may contribute to kidney disease.

    • Esteban E. Elias
    • Brayden Lyons
    • Daniel A. Muruve
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 337-350

  • In this Review, the authors discuss the biology of canonical and non-canonical inflammasomes and inflammasome-forming genes in the kidney, including their different functions in the various kidney compartments and their potential as therapeutic targets.

    • Takanori Komada
    • Daniel A. Muruve
    Reviews
    Nature Reviews Nephrology
    Volume: 15, P: 501-520