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Autocrine vitamin D signaling switches off pro-inflammatory programs of T_H1 cells

During homeostasis T_H1 cells activate a cell-intrinsic inflammatory shutdown program and shift to IL-10 production. Chauss et al. find that this T_H1 homeostatic program is dependent on vitamin D signaling and is disrupted in severe COVID-19.

Daniel Chauss
Tilo Freiwald
Behdad Afzali
Research11 Nov 2021
Nature Immunology

Volume: 23, P: 62-74
Transcription factor EGR2 controls homing and pathogenicity of T_H17 cells in the central nervous system

Lazarevic and colleagues show that the transcription factor EGR2 controls a transcriptional program specific to pathogenic T_H17 cells in the CNS.

Yuanyuan Gao
Yan Wang
Vanja Lazarevic
Research13 Jul 2023
Nature Immunology

Volume: 24, P: 1331-1344
Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells

Chen Yao
Guohua Lou
Tuoqi Wu
Amendments and Corrections03 Mar 2021
Nature Immunology

Volume: 22, P: 530
Human retinoic acid–regulated CD161⁺ regulatory T cells support wound repair in intestinal mucosa

T_reg cells are essential for enforcing peripheral tolerance but can also influence tissue regeneration. Afzali and colleagues use high-dimensional analysis to describe a distinct population of CD161⁺ human T_reg cells involved in wound healing of the intestinal mucosa.

Giovanni A. M. Povoleri
Estefania Nova-Lamperti
Behdad Afzali
Research05 Nov 2018
Nature Immunology

Volume: 19, P: 1403-1414
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells

Tuoqi Wu and colleagues show that the transcriptional repressor BACH2 is required early after chronic viral infection to enforce a stem-like fate in activated CD8⁺ T cells. BACH2 acts to suppress genes that lead to the exhausted cell state.

Chen Yao
Guohua Lou
Tuoqi Wu
Research11 Feb 2021
Nature Immunology

Volume: 22, P: 370-380

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Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells

Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system

Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

Human retinoic acid–regulated CD161+ regulatory T cells support wound repair in intestinal mucosa

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

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Quick links

Autocrine vitamin D signaling switches off pro-inflammatory programs of T_H1 cells

Transcription factor EGR2 controls homing and pathogenicity of T_H17 cells in the central nervous system

Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells

Human retinoic acid–regulated CD161⁺ regulatory T cells support wound repair in intestinal mucosa

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells