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Erratum: Ontogeny and homeostasis of CNS myeloid cells

Marco Prinz
Daniel Erny
Nora Hagemeyer
Amendments and Corrections19 Jul 2017
Nature Immunology

Volume: 18, P: 951
A compact and cost-effective hard X-ray free-electron laser driven by a high-brightness and low-energy electron beam

The first lasing results at SwissFEL, an X-ray free-electron laser, are presented, highlighting the facility’s unique capabilities. A general comparison to other major facilities is also provided.

Eduard Prat
Rafael Abela
Elke Zimoch
Research09 Nov 2020
Nature Photonics

Volume: 14, P: 748-754
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome

Zeiser and colleagues show that CAR T cell therapy results in upregulation of the TGFβ-activated kinase-1 (TAK1)–NF-κB–p38 MAPK pathway in microglia, causing neurocognitive defects, and find that TAK1 inhibition can reduce immune effector cell-associated neurotoxicity syndrome.

Janaki Manoja Vinnakota
Francesca Biavasco
Robert Zeiser
Research13 May 2024
Nature Cancer

Volume: 5, P: 1227-1249
Host microbiota constantly control maturation and function of microglia in the CNS

In this study, the authors show that host microbiota play a key role in modulating microglia homeostasis. Germ-free mice or mice with only limited microbiota complexity displayed defects in microglial cell proportions and maturation, leading to impaired innate immune responses. The authors find that short-chain fatty acid signaling regulates these effects in vivo.

Daniel Erny
Anna Lena Hrabě de Angelis
Marco Prinz
Research01 Jun 2015
Nature Neuroscience

Volume: 18, P: 965-977
Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

Using three-dimensional correlative light and electron microscopy of Lewy bodies and Lewy neurites in postmortem brains of Parkinson’s disease patients, researchers show that the major constituents are membranes rather than proteinaceous filaments.

Sarah H. Shahmoradian
Amanda J. Lewis
Matthias E. Lauer
Research24 Jun 2019
Nature Neuroscience

Volume: 22, P: 1099-1109
Gut microbes augment neurodegeneration

Bacterial residents of the human body often provide beneficial effects, but some can be harmful. The action of gut bacteria has been found to be tightly linked to neurodegeneration in a mouse model of Parkinson's disease.

Daniel Erny
Marco Prinz
News & Views12 Apr 2017
Nature

Volume: 544, P: 304-305
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N⁶-carboxymethyllysine

Due to a microbiota-dependent increase in intestinal permeability with age, the gut metabolite N⁶-carboxymethyllysine accumulates in the microglia of mouse and human brains. As a result, microglia display increased oxidative stress and mitochondrial dysfunction.

Omar Mossad
Bérénice Batut
Thomas Blank
Research03 Mar 2022
Nature Neuroscience

Volume: 25, P: 295-305
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

This study describes the transcriptional programming of yolk sac–derived microglia specification in the brain, in which c-kit–positive erythromyeloid cells are further modified into three developmental subpools of microglia progenitors and their microglia differentiation is mediated by the transcription factors Pu.1 and IRF8.

Katrin Kierdorf
Daniel Erny
Marco Prinz
Research20 Jan 2013
Nature Neuroscience

Volume: 16, P: 273-280
Microbiota-dependent increase in δ-valerobetaine alters neuronal function and is responsible for age-related cognitive decline

This study shows that age-related cognitive decline is alleviated by heterochronic microbiota transplantation in mice and that δ-valerobetaine, a microbiota-derived metabolite that increases with age in both mice and humans, alters neuronal and cognitive processes.

Omar Mossad
Elisa Nent
Thomas Blank
Research20 Dec 2021
Nature Aging

Volume: 1, P: 1127-1136
Ontogeny and homeostasis of CNS myeloid cells

Microglia are by far the best-characterized macrophages in the CNS, but non-parenchymal populations, such as those found in the meninges, are being increasingly studied. Prinz et al. review the ontogeny and functions of both parenchymal macrophages and non-parenchymal macrophages the CNS.

Marco Prinz
Daniel Erny
Nora Hagemeyer
Reviews22 Mar 2017
Nature Immunology

Volume: 18, P: 385-392
Microglia contribute to the propagation of Aβ into unaffected brain tissue

This study shows that Aβ from transgenic host tissue is able to enter and deposit within wild-type grafts via microglia, thus identifying microglia as carriers of Aβ deposition into previously unaffected brain tissue.

Paolo d’Errico
Stephanie Ziegler-Waldkirch
Melanie Meyer-Luehmann
ResearchOpen Access22 Nov 2021
Nature Neuroscience

Volume: 25, P: 20-25
Seed-induced Aβ deposition alters neuronal function and impairs olfaction in a mouse model of Alzheimer’s disease

Stephanie Ziegler-Waldkirch
Marina Friesen
Melanie Meyer-Luehmann
ResearchOpen Access22 Jul 2022
Molecular Psychiatry

Volume: 27, P: 4274-4284

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