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Showing 101–150 of 156 results

Advanced filters: Author: Daniel Frey Clear advanced filters

Chronic liver disease is an important risk factor for worse outcomes in acute pancreatitis: a systematic review and meta-analysis

Jakub Hoferica
Ruben Zsolt Borbély
Péter Jenő Hegyi
ResearchOpen Access19 Jul 2024
Scientific Reports

Volume: 14, P: 1-13
Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands

DNMT3A PWWP domain mutations promote localization of DNMT3A to CpG islands in a PRC1-dependent manner. DNMT3A interacts with H2AK119ub-modified nucleosomes.

Daniel N. Weinberg
Phillip Rosenbaum
C. David Allis
Research13 May 2021
Nature Genetics

Volume: 53, P: 794-800
Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer

Benedek Dankó
Julia Hess
Martin Selmansberger
ResearchOpen Access23 May 2024
npj Precision Oncology

Volume: 8, P: 1-20
Chronic Continuous or Intermittent Infusion of Cocaine Differentially Alter the Concentration of Neurotensin-like Immunoreactivity in Specific Rat Brain Regions

Scott T. Cain
Daniel Griff
Charles B. Nemeroff
Research01 May 1993
Neuropsychopharmacology

Volume: 8, P: 259-265
A phase II trial of marimastat in advanced pancreatic cancer

J D Evans
A Stark
J P Neoptolemos
ResearchOpen Access11 Dec 2001
British Journal of Cancer

Volume: 85, P: 1865-1870
Elementary school teachers’ perspectives about learning during the COVID-19 pandemic

Aymee Alvarez-Rivero
Candice Odgers
Daniel Ansari
ResearchOpen Access18 Sept 2023
npj Science of Learning

Volume: 8, P: 1-10
Characterization of experimental diabetic neuropathy using multicontrast magnetic resonance neurography at ultra high field strength

Daniel Schwarz
Asa S. Hidmark
Thomas Fleming
ResearchOpen Access05 May 2020
Scientific Reports

Volume: 10, P: 1-12
A genetically encoded photoactivatable Rac controls the motility of living cells

The precise spatiotemporal dynamics of protein activity remain poorly understood, yet they can be critical in determining cell behaviour. A genetically encoded, photoactivatable version of the protein Rac1, a key GTPase regulating actin cytoskeletal dynamics, has now been produced; this approach enables the manipulation of the activity of Rac1 at precise times and places within a living cell, thus controlling motility.

Yi I. Wu
Daniel Frey
Klaus M. Hahn
Research19 Aug 2009
Nature

Volume: 461, P: 104-108
Kinin B₁ and B₂ receptors mediate cancer pain associated with both the tumor and oncology therapy using aromatase inhibitors

Indiara Brusco
Gabriela Becker
Sara Marchesan Oliveira
ResearchOpen Access17 Mar 2023
Scientific Reports

Volume: 13, P: 1-16
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

H3K36me2 targets DNMT3A to intergenic regions and this process, together with H3K36me3-mediated recruitment of DNMT3B, has a key role in establishing and maintaining genomic DNA methylation landscapes.

Daniel N. Weinberg
Simon Papillon-Cavanagh
Chao Lu
Research04 Sept 2019
Nature

Volume: 573, P: 281-286
Spontaneous motion in hierarchically assembled active matter

Active materials are hierarchically assembled, starting from extensile microtubule bundles, to form emulsions with unexpected collective biomimetic properties such as autonomous motility.

Tim Sanchez
Daniel T. N. Chen
Zvonimir Dogic
Research07 Nov 2012
Nature

Volume: 491, P: 431-434
Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis

Steinberg et al. explore the associations between the nasal microbiota, respiratory tract infections (RTIs) and antibiotics in infants with cystic fibrosis (CF) and controls during the first year of life. Infants with CF have a different microbiota before their first RTI or antibiotic treatment, with lower diversity linked to higher number of RTIs.

Ruth Steinberg
Nadja Mostacci
Insa Korten
ResearchOpen Access23 Nov 2024
Communications Medicine

Volume: 4, P: 1-10
Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
Amendments and CorrectionsOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1
Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response

Victoria S. Marshe
Malgorzata Maciukiewicz
Daniel J. Müller
ResearchOpen Access15 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-12
Modulation of neural oscillations in escitalopram treatment: a Canadian biomarker integration network in depression study

Benjamin Schwartzmann
Raaj Chatterjee
Faranak Farzan
ResearchOpen Access12 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-11
Ultrasound education improves safety for peripheral intravenous catheter insertion in critically ill children

Vidit Bhargava
Erik Su
Katherine M. Steffen
Research01 Jun 2021
Pediatric Research

Volume: 91, P: 1057-1063
Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions

Distinct patterns of exposure to a first-line tuberculosis drug in separate lung lesions within patients are revealed by PET–CT imaging. Use of the technique might help optimize the duration and dosing of antimicrobial drugs.

Alvaro A. Ordonez
Hechuan Wang
Sanjay K. Jain
Research17 Feb 2020
Nature Medicine

Volume: 26, P: 529-534
Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort

Takaki Oka
Yuki Matsuzawa
Balebail Ashok Raj
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Pancreatic adenocarcinoma cells drive autophagy in tumour microenvironment-associated stellate cells, which release alanine that is used by the cancer cells as a carbon source for a variety of metabolic processes in an otherwise nutrient-poor environment.

Cristovão M. Sousa
Douglas E. Biancur
Alec C. Kimmelman
Research10 Aug 2016
Nature

Volume: 536, P: 479-483
webKnossos: efficient online 3D data annotation for connectomics

webKnossos is a browser-based tracing and annotation tool for 3D electron microscopy data sets that is optimized for seamless data viewing. The tool’s flight-mode view facilitates fast neurite tracing because of its egocentric viewpoint.

Kevin M Boergens
Manuel Berning
Moritz Helmstaedter
Research12 Jun 2017
Nature Methods

Volume: 14, P: 691-694
Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study

Farhana Islam
Victoria S. Marshe
Daniel J. Müller
ResearchOpen Access06 Sept 2022
Translational Psychiatry

Volume: 12, P: 1-11
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
Microbial controls over soil priming effects under chronic nitrogen and phosphorus additions in subtropical forests

Jian Li
Zhan-Feng Liu
Yong-Guan Zhu
Research29 Sept 2023
The ISME Journal

Volume: 17, P: 2160-2168
The Structure and Bacterial Expression of Three Distinct Bovine Interferon-β Genes

David W. Leung
Daniel J. Capon
David V. Goeddel
Research01 May 1984
Bio/Technology

Volume: 2, P: 458-464
Expanded dataset of mechanical properties and observed phases of multi-principal element alloys

Christopher K. H. Borg
Carolina Frey
James E. Saal
ResearchOpen Access08 Dec 2020
Scientific Data

Volume: 7, P: 1-6
The trend of disruption in the functional brain network topology of Alzheimer’s disease

Alireza Fathian
Yousef Jamali
Ansgar J. Furst
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-17
A standardized workflow for long-term longitudinal actigraphy data processing using one year of continuous actigraphy from the CAN-BIND Wellness Monitoring Study

Anastasiya Slyepchenko
Rudolf Uher
Benicio N. Frey
ResearchOpen Access15 Sept 2023
Scientific Reports

Volume: 13, P: 1-13
Resting-state EEG delta and alpha power predict response to cognitive behavioral therapy in depression: a Canadian biomarker integration network for depression study

Benjamin Schwartzmann
Lena C. Quilty
Faranak Farzan
ResearchOpen Access24 May 2023
Scientific Reports

Volume: 13, P: 1-12
A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors

Marwa Amer
Oneda Leka
Richard A. Kammerer
ResearchOpen Access22 Jun 2023
Scientific Reports

Volume: 13, P: 1-11
Gray matter volume drives the brain age gap in schizophrenia: a SHAP study

Pedro L. Ballester
Jee Su Suh
Benicio N. Frey
ResearchOpen Access09 Jan 2023
Schizophrenia

Volume: 9, P: 1-8
Cloning of breakpoints in and downstream the IGF2 gene that are associated with overexpression of IGF2 transcripts in colorectal tumours

Didier Hodzic
Bruno Frey
Rosita Winkler
Research18 Aug 1999
Oncogene

Volume: 18, P: 4710-4717
Prematurity Is Related to High Placental Cortisol in Preeclampsia

Myriam Aufdenblatten
Marc Baumann
Markus G Mohaupt
Research01 Feb 2009
Pediatric Research

Volume: 65, P: 198-202
Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

Sheng-Yao Huang
Jung-Lung Hsu
Balebail Ashok Raj
ResearchOpen Access14 Sept 2018
Scientific Reports

Volume: 8, P: 1-11
A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data

Suprateek Kundu
Joshua Lukemire
Ansgar J. Furst
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-18
Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient- and rater-blinded, randomized, controlled trial

Arun K. Tiwari
Clement C. Zai
James L. Kennedy
ResearchOpen Access14 Mar 2022
Translational Psychiatry

Volume: 12, P: 1-10
Robust Identification of Alzheimer’s Disease subtypes based on cortical atrophy patterns

Jong-Yun Park
Han Kyu Na
Balebail Ashok Raj
ResearchOpen Access09 Mar 2017
Scientific Reports

Volume: 7, P: 1-14
Insect reproductive behaviors are important mediators of carrion nutrient release into soil

Brooke K. Woelber-Kastner
Serita D. Frey
Carrie L. Hall
ResearchOpen Access11 Feb 2021
Scientific Reports

Volume: 11, P: 1-9
Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report

Antoine Yrondi
Laura M. Fiori
Gustavo Turecki
ResearchOpen Access08 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-7
IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice

Carolin Koss et al. show that IL-36 produced from neutrophils is a key amplifier of lung inflammation in mice by activating neutrophils, macrophages and fibroblasts in cooperation with GM-CSF and the viral mimic poly(I:C). This study suggests that targeting IL-36 may improve the treatment of neutrophilic lung diseases.

Carolin K. Koss
Christian T. Wohnhaas
Karim C. El Kasmi
ResearchOpen Access08 Feb 2021
Communications Biology

Volume: 4, P: 1-15
Treatment-emergent and trajectory-based peripheral gene expression markers of antidepressant response

Laura M. Fiori
Massimiliano Orri
Gustavo Turecki
ResearchOpen Access21 Aug 2021
Translational Psychiatry

Volume: 11, P: 1-8
Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report

Caspani et al. report on sex-specific plasma lipoproteins predictive of response to two commonly used antidepressants. The authors show that lipoproteins belonging to the same main class but differing in size and density exhibit distinct associations with depression and with response to pharmacotherapy, highlighting the importance of evaluating lipoprotein subclass in depression research.

Giorgia Caspani
Gustavo Turecki
Jonathan R. Swann
ResearchOpen Access22 Jul 2021
Communications Biology

Volume: 4, P: 1-11
Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations

David C. Yeomans
Leah R. Hanson
William H. Frey II
ResearchOpen Access10 Jul 2021
Translational Psychiatry

Volume: 11, P: 1-10
Polo-like kinases in the nervous system

Daniel P Seeburg
Daniel Pak
Morgan Sheng
Reviews10 Jan 2005
Oncogene

Volume: 24, P: 292-298
Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

This protocol describes the analysis of stable isotope (¹³C and ¹⁵N) incorporation into polar metabolites in central carbon metabolic pathways using HILIC separation and selected reaction monitoring with a hybrid triple quadrupole mass spectrometer.

Min Yuan
Daniel M. Kremer
John M. Asara
Protocols25 Jan 2019
Nature Protocols

Volume: 14, P: 313-330
Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants

Chelsey Ju
Laura M. Fiori
Gustavo Turecki
ResearchOpen Access08 Oct 2019
Translational Psychiatry

Volume: 9, P: 1-12
Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations

Sarah Bianchi
Wilhelmina E. van Riel
Richard A. Kammerer
ResearchOpen Access03 Aug 2016
Scientific Reports

Volume: 6, P: 1-16
Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus

Stephen C. Becker
Dwayne R. Roach
David M. Donovan
ResearchOpen Access28 Apr 2016
Scientific Reports

Volume: 6, P: 1-10
Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the canadian biomarker integration network in depression

Faranak Farzan
Sravya Atluri
Sidney H. Kennedy
ResearchOpen Access07 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology

Lutnick et al. develop a cloud-based deep learning tool for whole slide image segmentation. The authors provide several examples of its application in renal pathology, for segmenting glomeruli, interstitial fibrosis and other features of interest.

Brendon Lutnick
David Manthey
Angela Victoria-Castro
ResearchOpen Access19 Aug 2022
Communications Medicine

Volume: 2, P: 1-15
Establishing standardized immune phenotyping of metastatic melanoma by digital pathology

The authors present a robust diagnostic algorithm based on digital pathology and image analysis that quantifies intratumoral and stromal CD8+ T-cell densities in the tumor center and invasive margin compartment in metastatic melanoma. Spatial CD8+ T-cell densities are translated into the clinically relevant immune diagnostic categories “inflamed”, “excluded”, and “desert”. Their approach also allows efficient immune phenotyping of metastatic lesions, on biopsy material or even in the absence of material from the invasive margin.

Bettina Sobottka
Marta Nowak
Viktor Hendrik Koelzer
ResearchOpen Access26 Aug 2021
Laboratory Investigation

Volume: 101, P: 1561-1570

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