Nature Search

Tetrahydrobiopterin enhances regulatory T- and mast cell proliferation and alters cytokines expression in a murine heart transplant model

Susanne Ebner
Bernhard Texler
Manuel Maglione
ResearchOpen Access16 Oct 2025
Scientific Reports

Volume: 15, P: 1-15
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
A generic strategy for CRISPR-Cas9-mediated gene tagging

CRISPR-Cas9 has greatly enhanced genome engineering however gene tagging can still be cumbersome due to a requirement for homology donors. Here the authors introduce a generic system for gene tagging that does not require homology between the donor and the genomic target site.

Daniel H. Lackner
Alexia Carré
Tilmann Bürckstümmer
ResearchOpen Access17 Dec 2015
Nature Communications

Volume: 6, P: 1-7
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

Tyler J. Curiel
Shuang Wei
Weiping Zou
Research21 Apr 2003
Nature Medicine

Volume: 9, P: 562-567
Fast-exchanging spirocyclic rhodamine probes for aptamer-based super-resolution RNA imaging

Live-cell RNA imaging with high spatial and temporal resolution remains a major challenge. Here the authors design spirocyclic rhodamine probes that enable a fluorescent light-up aptamer system suitable for visualizing RNAs in live or fixed cells with two different super-resolution microscopy modalities SMLM and STED.

Daniel Englert
Eva-Maria Burger
Murat Sunbul
ResearchOpen Access30 Jun 2023
Nature Communications

Volume: 14, P: 1-13
Observation of magnetic islands in tokamak plasmas during the suppression of edge-localized modes

The suppression of edge-localized modes in tokamak plasmas is crucial to prevent them from damaging the walls of the chamber. Now experiments confirm the role that magnetic islands play in suppressing these detrimental modes.

Matthias Willensdorfer
Verena Mitterauer
S. Zoletnik
ResearchOpen Access28 Oct 2024
Nature Physics

Volume: 20, P: 1980-1988
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1

Some cancer cells lacking telomerase activity extend their telomeres via an alternative, recombination-based mechanism, termed ALT. A new study shows that depletion of histone chaperone ASF1 can induce ALT in both primary and cancer cells, suggesting that the ALT pathway may be triggered by changes in chromatin state.

Roderick J O'Sullivan
Nausica Arnoult
Jan Karlseder
Research12 Jan 2014
Nature Structural & Molecular Biology

Volume: 21, P: 167-174
Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma

Carolin Lackner
Luca Quagliata
Michal Kovac
ResearchOpen Access14 Mar 2019
Scientific Reports

Volume: 9, P: 1-6
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

Tyler J Curiel
George Coukos
Weiping Zou
Research22 Aug 2004
Nature Medicine

Volume: 10, P: 942-949
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

Michele Vacca
Ioannis Kamzolas
Antonio Vidal-Puig
ResearchOpen Access12 Jun 2024
Nature Metabolism

Volume: 6, P: 1178-1196
Super-resolution RNA imaging using a rhodamine-binding aptamer with fast exchange kinetics

A light-up RNA aptamer enables single-molecule localization microscopy with a resolution not limited by photobleaching.

Murat Sunbul
Jens Lackner
Andres Jäschke
Research11 Feb 2021
Nature Biotechnology

Volume: 39, P: 686-690
The RESOLUTE consortium: unlocking SLC transporters for drug discovery

The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.

Giulio Superti-Furga
Daniel Lackner
Claire M. Steppan
Comments & Opinion07 Apr 2020
Nature Reviews Drug Discovery

Volume: 19, P: 429-430
A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types

Marie-Claire Wagle
Daniel Kirouac
Shih-Min A. Huang
ResearchOpen Access07 Mar 2018
npj Precision Oncology

Volume: 2, P: 1-12
Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer

Multiregional analysis in 54 childhood cancers highlights four evolutionary patterns of intratumoral variation. Multiple patterns are often found in the same tumor, suggesting that tumors follow different evolutionary strategies concurrently.

Jenny Karlsson
Anders Valind
David Gisselsson
Research04 Jun 2018
Nature Genetics

Volume: 50, P: 944-950
Endophenotype Network Models: Common Core of Complex Diseases

Susan Dina Ghiassian
Jörg Menche
Joseph Loscalzo
ResearchOpen Access09 Jun 2016
Scientific Reports

Volume: 6, P: 1-13
Insights into functional bacterial diversity and its effects on Alpine bog ecosystem functioning

Anastasia Bragina
Christian Berg
Gabriele Berg
ResearchOpen Access06 Jun 2013
Scientific Reports

Volume: 3, P: 1-8

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