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Showing 1–7 of 7 results
Advanced filters: Author: Daniel Holoch Clear advanced filters

  • Conventional in situ hybridization protocols lead to loss of microRNAs, which diffuse out of the formaldehyde-fixed sample owing to their small size. Adding a carbodiimide that stably links the microRNA with the protein matrix around it prevents this diffusion and allows detection of miRNAs at very low expression levels.

    • John T G Pena
    • Cherin Sohn-Lee
    • Thomas Tuschl
    Research
    Nature Methods
    Volume: 6, P: 139-141

  • New small-molecule inhibitors of the histone methyltransferase PRC2 interfere with the allosteric activation of enzymatic activity. These compounds are effective against PRC2-dependent tumors that are resistant to catalytic inhibitors and provide important new tools for altering chromatin regulation.

    • Daniel Holoch
    • Raphaël Margueron
    News & Views
    Nature Chemical Biology
    Volume: 13, P: 345-346

  • H3K9me3 and H3K27me3 chromatin silencing marks are usually deposited by different SET-domain proteins. Here the authors show that the Enhancer-of-zeste-like protein Ezl1, from the unicellular eukaryote Paramecium tetraurelia, catalyzes methylation of histone H3 in vitro and in vivo with an apparent specificity toward K9 and K27, and controls the repression of transposable elements.

    • Andrea Frapporti
    • Caridad Miró Pina
    • Sandra Duharcourt
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Small and long non-coding RNAs have emerged as key regulators of gene expression through their direct and indirect actions on chromatin. This Review describes how RNAs form powerful surveillance systems that detect and silence inappropriate transcription events, and how such systems provide a memory of these events via self-reinforcing epigenetic loops.

    • Daniel Holoch
    • Danesh Moazed
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 71-84