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Showing 1–6 of 6 results
Advanced filters: Author: Daniel Huebschmann Clear advanced filters

  • Integrating complex multi-omics data for individual patient decision making can be challenging. Here, the authors develop Knowledge Connector as a decision support system to generate and document Molecular Tumor Board recommendations and support medical decision-making.

    • Daniel Hübschmann
    • Simon Kreutzfeldt
    • Peter Horak
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12

  • Primary lymphomas of the central nervous system (PCNSL) are defined as diffuse large B-cell lymphomas (DLBCL) confined to the CNS. Here, the authors complete whole genome sequencing and RNA-seq to characterize 51 PCNSLs, and find common mutations in immune pathways and upregulated TERT expression and find distinct pathway differences between DLBCL and other primary CNS lymphomas.

    • Josefine Radke
    • Naveed Ishaque
    • Frank L. Heppner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that underpin this disease how alterations on different cellular levels cooperate in deregulating key pathways and complexes.

    • Cristina López
    • Kortine Kleinheinz
    • Reiner Siebert
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • The evolution and genetic nature of metastatic lesions is not completely characterized. Here the authors perform a comprehensive whole-genome study of colorectal metastases in comparison to matched primary tumors and define a multistage progression model and metastasis-specific changes that, in part, are therapeutically actionable.

    • Naveed Ishaque
    • Mohammed L. Abba
    • Heike Allgayer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14