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  • The inhibitory receptor CTLA-4 recognizes two ligands on opposing antigen-presenting cells, CD80 and CD86. Sansom and colleagues show CTLA-4 captures ligands by transendocytosis, whereupon low-affinity CD86 releases CTLA-4 at low pH to promote CTLA-4 recycling; however, high-affinity CD80 remains bound and targets CTLA-4 for ubiquitination and destruction.

    • Alan Kennedy
    • Erin Waters
    • David M. Sansom
    ResearchOpen Access
    Nature Immunology
    Volume: 23, P: 1365-1378