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Showing 1–4 of 4 results
Advanced filters: Author: Daniel Jimenez-Carretero Clear advanced filters

  • Adipose tissue accommodates large volume changes upon expansion, but the molecular mechanisms involved are not fully understood. Here, Aboy et al. describe CAV1 Y14 phosphorylation as required for appropriate adipocyte caveolae flattening and homeostasis.

    • María C. M. Aboy-Pardal
    • Marta C. Guadamillas
    • Miguel A. Del Pozo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-27

  • Lolo et al. show caveolin-1 functions in non-caveolae structures termed dolines. Whereas caveolae respond to high forces over a mechanical threshold, dolines transduce low and medium mechanical forces gradually in a complementary buffering system.

    • Fidel-Nicolás Lolo
    • Nikhil Walani
    • Miguel A. del Pozo
    ResearchOpen Access
    Nature Cell Biology
    Volume: 25, P: 120-133

  • The cardiac conduction system dictates the pacing of the heartbeat, but despite its importance relatively little is known about the mechanisms underlying its development. Here they show that the G4 resolvase Dhx36 is important for regulating cardiac conduction system morphogenesis and function.

    • Pablo Gómez-del Arco
    • Joan Isern
    • Juan Miguel Redondo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth relies on RXR-dependent LPMs. 

    • María Casanova-Acebes
    • María Piedad Menéndez-Gutiérrez
    • Mercedes Ricote
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13