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Showing 1–7 of 7 results
Advanced filters: Author: Daniel Münter Clear advanced filters

  • Embryonal tumour with multilayered rosettes (ETMR) is a rare and aggressive paediatric brain tumour. Here, the authors analyse intratumour heterogeneity and the tumour microenvironment in ETMR using single-cell and spatial transcriptomics, in vitro cultures, and a 3D forebrain organoid model, finding important aspects – such as the communication with pericytes – for ETMR development and response to therapy.

    • Flavia W. de Faria
    • Nicole C. Riedel
    • Kornelius Kerl
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous and aggressive type of T-cell lymphoma. Here, the authors perform single-cell analyses of human and murine PTCL-NOS tumors, and identify a subtype defined by the loss of SMARCB1 that could be targeted with HDAC-inhibitor combination therapies.

    • Anja Fischer
    • Thomas K. Albert
    • Kornelius Kerl
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Paediatric high-grade gliomas with MYCN amplification (HGG-MYCN) are rare and highly aggressive. Here, the authors generate a mouse model for HGG-MYCN that can recapitulate the histological and molecular profiles of the human tumours, and perform high-throughput drug screening to identify potential treatment options.

    • Melanie Schoof
    • Shweta Godbole
    • Ulrich Schüller
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • WNT-activating mutations in CTNNB1 are common in hepatoblastoma, but downstream molecular phenotypes are heterogenous. Using multiomic approaches, the authors identify distinct subgroups of hepatoblastoma cells based on WNT-signaling patterns and create a biobank of patient-derived hepatoblastoma organoids representing these subtypes.

    • Thomas A. Kluiver
    • Yuyan Lu
    • Weng Chuan Peng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The MAPK pathway is a key driver of pediatric low-grade gliomas (pLGG); however, response to MAPK inhibitors (MAPKi) in pLGG patients is not consistent. Here, the authors develop MAPKi sensitivity scores (MSS) to predict response to MAPKi and apply them to bulk and single-cell sequencing datasets from pLGG patients and preclinical models.

    • Romain Sigaud
    • Thomas K. Albert
    • Till Milde
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • How obesity contributes to COVID-19 severity is not fully understood. In this study, Yoshiji et al. found that the plasma protein nephronectin partially mediates the effect of obesity on the risk of COVID-19 severity using a two-step Mendelian randomization approach and omics analyses.

    • Satoshi Yoshiji
    • Guillaume Butler-Laporte
    • J. Brent Richards
    Research
    Nature Metabolism
    Volume: 5, P: 248-264