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Showing 1–15 of 15 results
Advanced filters: Author: Daniel M Greif Clear advanced filters

  • Hepatocytes regenerate the liver after injury, however, the tissue repair mechanisms have been little explored. Here, the authors show that midlobular and pericentral hepatocytes increase their number and size in response to chemical, physical, and viral insults facilitating liver regeneration.

    • Inmaculada Ruz-Maldonado
    • John T. Gonzalez
    • Carlos Fernández-Hernando
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-23

  • The pluripotency factor KLF4 has been described as pro-fibrotic or anti-fibrotic in various diseases. Herein, the authors show that during lung fibrosis, these distinct effects can be attributed to mesenchymal cell-type specific functions of KLF4.

    • Rachana R. Chandran
    • Yi Xie
    • Daniel M. Greif
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Smooth muscle cells (SMCs) invade atherosclerotic lesions and expand, contributing to plaque progression. Here Misra et al. show that SMC-derived plaque cells come from a single SMC and integrin β3 in SMCs and macrophages regulate the fate, expansion and migration of SMCs during plaque formation.

    • Ashish Misra
    • Zhonghui Feng
    • Daniel M. Greif
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • A study finds that contractile cells that surround the capillary vessels of the brain control the blood supply to healthy neurons, and that their death may aggravate brain injury by strangling vessels. See Article p.55

    • Daniel M. Greif
    • Anne Eichmann
    News & Views
    Nature
    Volume: 508, P: 50-51

  • Quantum gas microscopes provide high-resolution real-space snapshots of quantum many-body systems. Now machine-learning techniques are used in choosing theoretical descriptions according to the consistency of their predictions with these snapshots.

    • Annabelle Bohrdt
    • Christie S. Chiu
    • Michael Knap
    Research
    Nature Physics
    Volume: 15, P: 921-924

  • Revascularization of ischaemia-injured myocardium is critical for functional recovery. A new study shows that endothelial cells of neovessels in the injured heart derive from pre-existing endothelial cells. This new finding focuses research on therapeutic strategies to direct the neovasculature to deliver oxygen and nutrients effectively to the ischaemic myocardium.

    • Daniel M. Greif
    • Anne Eichmann
    News & Views
    Nature Reviews Cardiology
    Volume: 14, P: 507-508

  • Cellular senescence and smooth muscle cells are key features of the atherosclerotic plaque; however, how senescent cells regulate smooth muscle cells is largely unknown. Herein, a new study in Nature Aging illuminates this interplay, providing insights into plaque dynamics and stability with potentially profound implications for heart attack and stroke.

    • Inamul Kabir
    • Daniel M. Greif
    News & Views
    Nature Aging
    Volume: 1, P: 631-633

  • Pericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor proteins.

    • Alexandre Dubrac
    • Steffen E. Künzel
    • Anne Eichmann
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Vascular homeostasis in the lung is disturbed in pulmonary arterial hypertension. Jongmin Kim et al. delineate a new signaling axis controlling endothelial cell proliferation and cytokine production that is dysregulated in pulmonary endothelial cells from individuals with this disease. In this axis, the peptide apelin controls expression of the cytokine FGF2, a mitogen for endothelial and vascular smooth-muscle cells, through effects on two microRNAs. The authors also demonstrated the functional importance of these miRNAs in rat models of pulmonary hypertension.

    • Jongmin Kim
    • Yujung Kang
    • Hyung J Chun
    Research
    Nature Medicine
    Volume: 19, P: 74-82

  • Individual studies have been underpowered to draw clear associations between clonal heterogeneity and response to therapy in acute myeloid leukemia (AML). Here, the authors aggregate multiple AML cohorts and are able to correlate the clonal abundance of somatic mutations with clinical outcomes and drug sensitivity.

    • Brooks A. Benard
    • Logan B. Leak
    • Ravindra Majeti
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • An antiferromagnet with a correlation length that encompasses the whole system is created with the aid of quantum gas microscopy of cold atoms in an optical lattice.

    • Anton Mazurenko
    • Christie S. Chiu
    • Markus Greiner
    Research
    Nature
    Volume: 545, P: 462-466