Here, the authors investigate the proteome trajectory of human iPSCs differentiating into hepatic stellate cells (diHSCs) and identify RORA as a key transcription factor that governs metabolic reprogramming essential for diHSCs’ commitment, identity, and quiescent phenotype.
- Raquel A. Martínez García de la Torre
- Julia Vallverdú
- Pau Sancho-Bru