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dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening

Arrayed and pooled high-throughput screening is crucial for drug discovery and CRISPR functional genomics. Here, the authors present dFLASH; a dual FLuorescent transcription factor Activity Sensor for Histone-integrated live-cell reporting for high performance screening applications across numerous pathways and screening contexts.

Timothy P. Allen
Alison E. Roennfeldt
David C. Bersten
ResearchOpen Access07 Apr 2025
Nature Communications

Volume: 16, P: 1-18
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

Wesley et al. describe the developmental trajectories of human foetal liver cell types at single-cell resolution and generate bipotential hepatoblast organoids, which can serve as a new platform to investigate human liver development.

Brandon T. Wesley
Alexander D. B. Ross
Ludovic Vallier
Research15 Sept 2022
Nature Cell Biology

Volume: 24, P: 1487-1498
Attosecond delays in X-ray molecular ionization

Time-resolved measurements of the X-ray photoemission delay of core-level electrons using attosecond soft X-ray pulses from a free-electron laser can be used to determine the complex correlated dynamics of photoionization.

Taran Driver
Miles Mountney
James P. Cryan
Research21 Aug 2024
Nature

Volume: 632, P: 762-767
A vascularized breast cancer spheroid platform for the ranked evaluation of tumor microenvironment-targeted drugs by light sheet fluorescence microscopy

Assessing tumour microenvironment-targeted drug candidates remains challenging. Here, the authors develop a comprehensive screening platform that allows for monitoring, quantifying, and ranking drug-induced effects in self-organizing, vascularized tumour spheroids.

David Ascheid
Magdalena Baumann
Erik Henke
ResearchOpen Access27 Apr 2024
Nature Communications

Volume: 15, P: 1-23
Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools

The heart is formed from several spatiotemporally distinct progenitor pools during development. Here they show that modulation of retinoic acid signaling can instruct human pluripotent stems cells into heart progenitors that are useful for studying human development and disease.

Dorota Zawada
Jessica Kornherr
Alexander Goedel
ResearchOpen Access03 Apr 2023
Nature Communications

Volume: 14, P: 1-20
Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation

Many stem cells exhibit cell division coupled to differentiation, though the changes occurring between consecutive cell divisions have been difficult to study. Here they use synchronized hPSC culture to show that production of transcription factors and epigenetic changes are linked with cell division timing.

Pedro Madrigal
Siwei Deng
Siim Pauklin
ResearchOpen Access25 Jan 2023
Nature Communications

Volume: 14, P: 1-23
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids

Repair of defects in the common bile duct is hampered by a lack of healthy donor tissue. Developing human extrahepatic cholangiocyte organoids and testing them in mouse models may provide a way to overcome this limitation.

Fotios Sampaziotis
Alexander W Justin
Ludovic Vallier
Research03 Jul 2017
Nature Medicine

Volume: 23, P: 954-963
Telomerase activation by genomic rearrangements in high-risk neuroblastoma

Activation of telomere maintenance mechanisms—caused by novel somatic rearrangements of TERT, by MYCN amplification, or ATRX mutations—is a hallmark of high-risk neuroblastomas.

Martin Peifer
Falk Hertwig
Matthias Fischer
Research14 Oct 2015
Nature

Volume: 526, P: 700-704
New bobtail squid (Sepiolidae: Sepiolinae) from the Ryukyu islands revealed by molecular and morphological analysis

Gustavo Sanchez et al. describe three species of bobtail squid from the Ryukyu archipelago using morphological analysis, mitochondrial sequences, and transcriptome sequences. One of these species was a previously unknown bobtail squid from the genus Euprymna, the second is reassigned to the genus Euprymna, and the third species is closely related to another bobtail squid endemic from Australia and East Timor.

Gustavo Sanchez
Jeffrey Jolly
Daniel S. Rokhsar
ResearchOpen Access11 Dec 2019
Communications Biology

Volume: 2, P: 1-15
Genetics of rheumatoid arthritis contributes to biology and drug discovery

A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological candidate genes that are either already being targeted by drugs or could be in the future.

Yukinori Okada
Di Wu
Robert M. Plenge
Research25 Dec 2013
Nature

Volume: 506, P: 376-381
The SMAD2/3 interactome reveals that TGFβ controls m⁶A mRNA methylation in pluripotency

The SMAD2 and SMAD3 protein interactome links TGFβ signalling to diverse effectors including m⁶A methyltransferase, which has a role in regulating differentiation of human pluripotent stem cells.

Alessandro Bertero
Stephanie Brown
Ludovic Vallier
Research28 Feb 2018
Nature

Volume: 555, P: 256-259
Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations

Henning Jacobsen
Monika Strengert
Luka Cicin-Sain
ResearchOpen Access18 Nov 2022
Scientific Reports

Volume: 12, P: 1-11
ATM activity in T cells is critical for immune surveillance of lymphoma in vivo

Arina Riabinska
Daria Lehrmann
Hans Christian Reinhardt
Research05 Nov 2019
Leukemia

Volume: 34, P: 771-786
Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations

Here, the authors introduce a metabolome-wide association study that combines a genome-wide association study of cerebrospinal fluid metabolites with publicly available genome-wide association study summary statistics of neurological and psychiatric conditions to identify 19 significant CSF metabolite-phenotype associations.

Daniel J. Panyard
Kyeong Mo Kim
Qiongshi Lu
ResearchOpen Access12 Jan 2021
Communications Biology

Volume: 4, P: 1-11

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