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Showing 1–4 of 4 results
Advanced filters: Author: Daniel P. Bondeson Clear advanced filters

  • The use of a high-affinity VHL ligand allows the development of chimeric molecules that promote the association of ERRα or RIPK2 with the VHL E3 ubiquitin ligase complex, resulting in protein degradation.

    • Daniel P Bondeson
    • Alina Mares
    • Craig M Crews
    Research
    Nature Chemical Biology
    Volume: 11, P: 611-617

  • XPR1 is the only annotated phosphate exporter protein in humans. Recent studies provide mechanistic clues to its cellular function; three posit non-export mechanisms to regulate phosphate homeostasis, while six present high-resolution cryo-EM data supporting a bona fide phosphate channel mechanism controlled by intracellular phosphate levels.

    • Daniel P. Bondeson
    News & Views
    Nature Structural & Molecular Biology
    Volume: 32, P: 5-7

  • Conditional Degron Tags are a valuable tool to validate and study novel therapeutic targets. Here, the authors compared 5 orthogonal tags across 16 unique proteins and provide a panel of vectors for users to systematically screen the tags with their own protein of interest.

    • Daniel P. Bondeson
    • Zachary Mullin-Bernstein
    • Alessandra Ianari
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11