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Showing 1–5 of 5 results
Advanced filters: Author: Daniel Parras Clear advanced filters

  • Long-term characterisation of SARS-CoV-2 antibody kinetics is needed to understand the protective role of the immune response. Here the authors describe antibody levels and neutralisation activity in healthcare workers over seven months and investigate the role of immunity to endemic human coronaviruses.

    • Natalia Ortega
    • Marta Ribes
    • Carlota Dobaño
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • In this study, He et al. find that the CHARGE syndrome–related chromatin remodeler Chd7 regulates the initiation of myelination and remyelination in the CNS. Chd7 interacts with Sox10 to orchestrate the transcriptional state of myelinogenic genes and serves as a molecular nexus of the regulatory networks that contribute to white matter pathogenesis in CHARGE syndrome.

    • Danyang He
    • Corentine Marie
    • Q Richard Lu
    Research
    Nature Neuroscience
    Volume: 19, P: 678-689

  • Recombinant MHC class II molecules are instrumental in antigen-specific T-cell identification assays and showed efficacy as experimental medicines. Here, the authors engineer MHC class II molecules with species-specific knob-into-hole heteromerization domains, enabling a translatable purification process with improved stability, yields, and biological potency.

    • Pau Serra
    • Nahir Garabatos
    • Pere Santamaria
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14