Nature Search

The DNA methylome of cervical cells can predict the presence of ovarian cancer

Most ovarian cancers originate from cells originally derived from Müllerian Duct cells. Here, the authors show that the methylation profile of Müllerian Duct cells isolated from cervical samples can predict whether a woman has cervical cancer.

James E. Barrett
Allison Jones
Martin Widschwendter
ResearchOpen Access01 Feb 2022
Nature Communications

Volume: 13, P: 1-12
The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples

Breast cancer is most commonly diagnosed via a needle biopsy. In this study, the authors show that cervical samples from women with breast cancer have a methylation signature different to that of healthy controls.

James E. Barrett
Chiara Herzog
Martin Widschwendter
ResearchOpen Access01 Feb 2022
Nature Communications

Volume: 13, P: 1-14
Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

Women with germline variants in BRCA genes are predisposed to ovarian cancer. In this study, the authors demonstrate that fimbrial tissue from the ovary, the site of ovarian cancer, in BRCAmutant carriers contains marked DNA methylation changes compared with the proximal region of the ovary.

Thomas E. Bartlett
Kantaraja Chindera
Martin Widschwendter
ResearchOpen Access24 May 2016
Nature Communications

Volume: 7, P: 1-10
Epigenome-based cancer risk prediction: rationale, opportunities and challenges

The development of cancer involves several epigenomic alterations, and the presence of certain alterations before the development of cancer is associated with cancer risk. In this Review, the authors describe the potential of epigenomics-based assays to predict an individual's risk of cancer, including discussions of technical, practical and societal issues regarding the implementation of such assays.

Martin Widschwendter
Allison Jones
Nora Pashayan
Reviews27 Feb 2018
Nature Reviews Clinical Oncology

Volume: 15, P: 292-309
Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity

Chris Barkus
Clio Korn
Elizabeth M Tunbridge
ResearchOpen Access08 Jul 2016
Neuropsychopharmacology

Volume: 41, P: 3060-3069

Quick links

Search

Filter By:

The DNA methylome of cervical cells can predict the presence of ovarian cancer

The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples

Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity

Search

Quick links