The pathogenic bacterium Pseudomonas aeruginosa can be found in vacuoles and cytoplasm within infected cells. Here, Schator et al. show that extracellular bacteria use a type-III secretion system to induce Ca2+ influx into host cells and promote vacuole escape of intracellular bacteria and in vivo dissemination.
- Daniel Schator
- Naren G. Kumar
- Suzanne M. J. Fleiszig