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Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

Arthur Gilly
Daniel Suveges
Eleftheria Zeggini
Amendments and CorrectionsOpen Access19 Dec 2018
Nature Communications

Volume: 9, P: 1
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

Rare genetic variants can contribute to complex traits but this contribution is not well understood. Here, the authors analyse deep whole genome sequencing data across 1457 individuals from an isolated Greek population and find association of rare variant burdens with cardiometabolic traits.

Arthur Gilly
Daniel Suveges
Eleftheria Zeggini
ResearchOpen Access07 Nov 2018
Nature Communications

Volume: 9, P: 1-9
Network expansion of genetic associations defines a pleiotropy map of human cell biology

Network expansion of trait-associated genes for 1,002 human phenotypes identifies pleiotropic gene modules and biological processes associated with multiple traits, and potential opportunities for drug repurposing and development.

Inigo Barrio-Hernandez
Jeremy Schwartzentruber
Pedro Beltrao
ResearchOpen Access23 Feb 2023
Nature Genetics

Volume: 55, P: 389-398
Whole-genome sequencing analysis of the cardiometabolic proteome

The human proteome represents a crucial link between complex disease and genetic/environmental factors. Here, the authors investigate 257 cardiometabolic-relevant protein biomarkers in whole genome sequencing data from 1328 individuals, revealing the genetic architecture underlying biomarker variation.

Arthur Gilly
Young-Chan Park
Eleftheria Zeggini
ResearchOpen Access10 Dec 2020
Nature Communications

Volume: 11, P: 1-9
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

Genome-wide association study for osteoarthritis using data from UK Biobank identifies loci for knee- and hip-specific disease. Functional analyses of chondrocytes provide further insight into candidate causal genes.

Eleni Zengini
Konstantinos Hatzikotoulas
Eleftheria Zeggini
Research20 Mar 2018
Nature Genetics

Volume: 50, P: 549-558
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

Isolated populations can provide useful information on low-frequency variants for dissecting genetic architecture of complex traits. Here, Zeggini and colleagues show enrichment of rare and low-frequency variants and 8 novel low-frequency variant signals for cardiometabolic traits in two Greek isolated populations

Lorraine Southam
Arthur Gilly
Eleftheria Zeggini
ResearchOpen Access26 May 2017
Nature Communications

Volume: 8, P: 1-11
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

Genome-wide meta-analysis of UK Biobank and arcOGEN (77,052 cases and 378,169 controls) identifies 52 new osteoarthritis risk loci. Integrated eQTL colocalization, fine-mapping, and rare-disease data identify putative effector genes for osteoarthritis.

Ioanna Tachmazidou
Konstantinos Hatzikotoulas
Eleftheria Zeggini
Research21 Jan 2019
Nature Genetics

Volume: 51, P: 230-236
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

Individuals from a Greenlandic Inuit population with homozygous loss-of-function variants in ADCY3 (adenylate cyclase 3) have increased risk for obesity and type 2 diabetes. Carriers of rare ADCY3 variants in trans-ancestry populations also show increased association with type 2 diabetes.

Niels Grarup
Ida Moltke
Torben Hansen
Research08 Jan 2018
Nature Genetics

Volume: 50, P: 172-174
Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations

Karoline Kuchenbaecker
Arthur Gilly
Eleftheria Zeggini
ResearchOpen Access21 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups

Tewodros Gebresilase
Chris Finan
Fasil Tekola-Ayele
ResearchOpen Access08 Feb 2021
Scientific Reports

Volume: 11, P: 1-11

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Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

Network expansion of genetic associations defines a pleiotropy map of human cell biology

Whole-genome sequencing analysis of the cardiometabolic proteome

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations

Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups

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