Nature Search

Mutations of tumor necrosis factor α-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability

Daniel T Starczynowski
Joseph G Reynolds
Thomas D Gilmore
Research18 Jul 2005
Oncogene

Volume: 24, P: 7355-7368
The c-Rel transcription factor and B-cell proliferation: a deal with the devil

Thomas D Gilmore
Demetrios Kalaitzidis
Daniel T Starczynowski
Reviews02 Feb 2004
Oncogene

Volume: 23, P: 2275-2286
Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells

Demetrios Kalaitzidis
John Ok
Thomas D Gilmore
Research23 Aug 2004
Oncogene

Volume: 23, P: 7580-7587
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

Starczynowski and colleagues show that myelodysplastic syndrome HSPCs have a competitive advantage as compared to normal HSPCs during chronic inflammation due to a switch from canonical to noncanonical signaling for the activation of NF-κB.

Tomoya Muto
Callum S. Walker
Daniel T. Starczynowski
Research20 Apr 2020
Nature Immunology

Volume: 21, P: 535-545
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Starczynowski and colleagues show that overexpression of TRAF6 in HSCs induces ubiquitination of the RNA-binding protein hnRNPA1 and alternative splicing of Arhgap1, which accounts for the hematopoietic defects in myelodysplastic syndromes.

Jing Fang
Lyndsey C Bolanos
Daniel T Starczynowski
Research26 Dec 2016
Nature Immunology

Volume: 18, P: 236-245
Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1

ADP-heptose binds to ALPK1, triggering transcriptional reprogramming and NF-κB activation, endowing pre-leukaemic cells with a competitive advantage due to excessive clonal proliferation.

Puneet Agarwal
Avery Sampson
Daniel T. Starczynowski
ResearchOpen Access23 Apr 2025
Nature

Volume: 642, P: 201-211
The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia

Madeline Niederkorn
Chiharu Ishikawa
Daniel T. Starczynowski
ResearchOpen Access31 Aug 2021
Leukemia

Volume: 36, P: 438-451
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

For myelodysplastic syndromes caused by deletion of chromosome 5q, Daniel Starczynowski et al. provide evidence that decreased expression of two miRNAs in this region—miR-145 and miR-146a—contributes to abnormal megakaryocyte differentiation and platelet production and progression of the disease to either bone marrow failure or leukemia. The authors also provide a mechanistic explanation for these effects by which loss of these two miRNAs leads to derepression of innate immune signaling.

Daniel T Starczynowski
Florian Kuchenbauer
Aly Karsan
Research08 Nov 2009
Nature Medicine

Volume: 16, P: 49-58
Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis

Patients with Acute myeloid leukemia (AML) who do not respond to standard chemotherapy have limited treatment options. Here, the authors show that high expression of the gene TNFAIP3/A20 in AML cells contributes to chemotherapy resistance by blocking a type of cell death called necroptosis.

Ashley E. Culver-Cochran
Aishlin Hassan
Daniel T. Starczynowski
ResearchOpen Access24 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes

Myelodysplastic syndrome (MDS) arises from mutations in hematopoietic stem cells (HSCs). Here, the authors demonstrate that HSCs in higher-risk MDS express the surface marker CD123 and are characterized by activation of protein synthesis machinery and increased oxidative phosphorylation.

Brett M. Stevens
Nabilah Khan
Craig T. Jordan
ResearchOpen Access12 Sept 2018
Nature Communications

Volume: 9, P: 1-14
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

Smith et al demonstrate that mutated splicing factor U2AF1 promotes expression of a longer isoform of IRAK4, leading to enhanced NF-kB activation and leukaemic growth in acute myeloid leukaemia.

Molly A. Smith
Gaurav S. Choudhary
Daniel T. Starczynowski
Research22 Apr 2019
Nature Cell Biology

Volume: 21, P: 640-650
Correction: Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Jing Fang
Lyndsey C Bolanos
Daniel T Starczynowski
Amendments and Corrections22 Mar 2017
Nature Immunology

Volume: 18, P: 474
Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization

Eric J. Vick
Aishlin Hassan
Daniel T. Starczynowski
ResearchOpen Access16 Jul 2025
Leukemia

Volume: 39, P: 2163-2173
Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome

Courtnee A. Clough
Claire Cunningham
Daniel Starczynowski
ResearchOpen Access30 Jun 2025
Leukemia

Volume: 39, P: 1997-2009
A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

Lenalidomide, which is used to treat myelodysplastic syndrome, kills mutation-bearing hematopoietic cells by increasing expression of the G-protein-coupled receptor GPR68, leading to increased intracellular calcium concentrations and calpain activation.

Jing Fang
Xiaona Liu
Daniel T Starczynowski
Research13 Jun 2016
Nature Medicine

Volume: 22, P: 727-734
IKAROS and MENIN in synergy in AML

Acute myeloid leukemia (AML) is characterized by distinct genetic and molecular alterations, including rearrangements in the mixed lineage leukemia (MLL) gene. A study now presents a therapeutic strategy for MLL-rearranged (MLL-r) AML that exploits a unique co-dependency on IKAROS and MENIN.

LaQuita M. Jones
Daniel T. Starczynowski
News & Views27 May 2022
Nature Cancer

Volume: 3, P: 528-529
IRAK signalling in cancer

G W Rhyasen
D T Starczynowski
ReviewsOpen Access07 Oct 2014
British Journal of Cancer

Volume: 112, P: 232-237
In situ mapping identifies distinct vascular niches for myelopoiesis

A combination of fluorescent antibodies is used to build visual maps of all myeloid cells in the bone marrow, providing new insight into how the bone marrow microenvironment regulates cell-fate decisions.

Jizhou Zhang
Qingqing Wu
Daniel Lucas
Research10 Feb 2021
Nature

Volume: 590, P: 457-462
RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia

William Marion
Tiago Koppe
R. Grant Rowe
Research30 Jun 2023
Leukemia

Volume: 37, P: 1698-1708
Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression

Shinichiro Matsui
Chihiro Ri
Tomoya Muto
ResearchOpen Access12 Apr 2024
Leukemia

Volume: 38, P: 1032-1045
DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy

Emily Stepanchick
Andrew Wilson
Timothy M. Chlon
ResearchOpen Access27 Jun 2024
Leukemia

Volume: 38, P: 1787-1798
FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome

Michael Schieber
Christian Marinaccio
John D. Crispino
ResearchOpen Access06 Oct 2020
Blood Cancer Journal

Volume: 10, P: 1-12
An MDS xenograft model utilizing a patient-derived cell line

G W Rhyasen
M Wunderlich
D T Starczynowski
Correspondence11 Dec 2013
Leukemia

Volume: 28, P: 1142-1145
Deregulation of microRNAs in myelodysplastic syndrome

G W Rhyasen
D T Starczynowski
Reviews19 Aug 2011
Leukemia

Volume: 26, P: 13-22
Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells

Daniel T Starczynowski
Joseph G Reynolds
Thomas D Gilmore
Research09 Oct 2003
Oncogene

Volume: 22, P: 6928-6936
Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome

M E Varney
K Choi
D T Starczynowski
Correspondence03 Oct 2016
Leukemia

Volume: 31, P: 491-495
Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes

Amer M. Zeidan
Jan Philipp Bewersdorf
Valeria Santini
Correspondence20 Oct 2022
Leukemia

Volume: 36, P: 2939-2946

Search

Mutations of tumor necrosis factor α-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability

The c-Rel transcription factor and B-cell proliferation: a deal with the devil

Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1

The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis

Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

Correction: Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization

Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome

A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

IKAROS and MENIN in synergy in AML

IRAK signalling in cancer

In situ mapping identifies distinct vascular niches for myelopoiesis

RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia

Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression

DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy

FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome

An MDS xenograft model utilizing a patient-derived cell line

Deregulation of microRNAs in myelodysplastic syndrome

Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells

Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome

Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes

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