This paper describes materials and design strategies for wireless, bioresorbable drug delivery devices that allow localized release of drugs in precisely controlled, patient-specific time sequences. The device architecture combines completely bioresorbable wireless electronics and thermally actuated lipid membranes infused with multiple types of drugs, to enable remote time-controlled release profiles with near-zero leakage in the off-state. Complete bioresorption following an engineered operational lifetime eliminates unnecessary patient risk and device load on the body, without the need for surgical extraction. Systematic in vivo and in vitro studies demonstrate the underlying principles and all of the relevant features of operation. The capabilities offered by this platform have potential utility in clinical therapies to improve patient compliance and the efficacy of current procedures.
- Chi Hwan Lee
- Hojun Kim
- John A Rogers
