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Showing 1–4 of 4 results
Advanced filters: Author: Daniel Wilinski Clear advanced filters

  • Members of the PUF family of RNA-binding proteins bind multiple mRNAs in vivo. Here the authors show that the S. cerevisiaePuf5p binds targets of varying lengths that correlate with biological functions. The RNA-binding sites adopt different structures to adapt to a fixed protein scaffold.

    • Daniel Wilinski
    • Chen Qiu
    • Marvin Wickens
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • The relationship between metabolomic and behavioral changes is not well understood. Here, the authors analyze metabolome changes in D. melanogaster heads and bodies during hunger and satiety, and develop the Flyscape tool to visualize the resulting metabolic networks and integrate them with other omics data.

    • Daniel Wilinski
    • Jasmine Winzeler
    • Monica Dus
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • A fusion of RNA-binding proteins (RBPs) to a poly(U) polymerase allows the tagging of endogenous RNAs bound by the RBPs with a U-tail that can be used to identify the bound RNA by sequencing. RNA tagging is suited to discover RNA-protein networks in vivo.

    • Christopher P Lapointe
    • Daniel Wilinski
    • Marvin Wickens
    Research
    Nature Methods
    Volume: 12, P: 1163-1170

  • Here, the authors demonstrate that the translation of the Drosophila transcript of insulin (dilp2) is regulated by methylation of N6-adenosine (m6A) in the 3′ UTR, at sites also conserved in mammals. In turn, this results in aberrant, diabetes-like functional phenotypes.

    • Daniel Wilinski
    • Monica Dus
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1260-1264