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Showing 1–2 of 2 results
Advanced filters: Author: Daniela Michelatti Clear advanced filters

  • Metastasis arises from disseminated tumour cells (DTCs) while the underlying mechanism of DTCs plasticity remains underexplored. Here, the authors show that spatially organized oncogenic enhancers on chromatin sustain the establishment of retinoic acid (RA)-stimulated transcriptional memory through activation of SOX9, supporting the escape of quiescent DTCs from NK-mediated immune surveillance.

    • Daniela Michelatti
    • Sven Beyes
    • Alessio Zippo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • MLL4 (KMT2D) loss of function, as found in Kabuki syndrome, affects the chromatin compartmentalization of Polycomb proteins and changes the nuclear architecture. Inhibition of ATR reestablishes mechanosignaling of mutant mesenchymal stem cells and their commitment to becoming chondrocytes.

    • Alessandra Fasciani
    • Sarah D’Annunzio
    • Alessio Zippo
    Research
    Nature Genetics
    Volume: 52, P: 1397-1411