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Showing 1–8 of 8 results
Advanced filters: Author: Danny Axford Clear advanced filters

  • Spatiotemporal insight into photoactivation of the prototypical B12 photoreceptor CarH is revealed across nine orders of magnitude in time, identifying a transient adduct that distinguishes it from thermally activated B12 enzymes.

    • Ronald Rios-Santacruz
    • Harshwardhan Poddar
    • Giorgio Schirò
    Research
    Nature
    P: 1-8

  • Archaerhodopsin-3 (AR3) mutants are commonly used in optogenetics for neuron silencing and membrane voltage sensing. High-resolution crystal structures show that desensitization of the AR3 photoreceptor occurs when internal hydrogen-bonded water networks are modified in response to changes in chromophore isomerization.

    • Juan F. Bada Juarez
    • Peter J. Judge
    • Anthony Watts
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Currently many of the time resolved serial femtosecond (SFX) crystallography experiments are done with light driven protein systems, whereas the reaction initiation for non-light triggered enzymes remains a major bottle neck. Here, the authors present an expanded Drop-on-Tape system, where picoliter-sized droplets of a substrate or inhibitor are turbulently mixed with nanoliter sized droplets of microcrystal slurries, and they use it for time-resolved SFX measurements of inhibitor binding to lysozyme and secondly, binding of a β-lactam antibiotic to a bacterial serine β-lactamase.

    • Agata Butryn
    • Philipp S. Simon
    • Allen M. Orville
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-7

  • Serial femtosecond crystallography and the use of X-ray free-electron lasers (XFEL) promise to revolutionize structural biology. Here, the authors describe refinements that reduce the redundancy required to obtain quality XFEL data and report a 1.75-Å structure—not obtainable by synchrotron radiation—using less than 6,000 crystals.

    • Helen M. Ginn
    • Marc Messerschmidt
    • David I. Stuart
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • The detailed mechanism of how non-enveloped viruses initiate infection remains obscure. Ren et al. present the atomic structure of an uncoating intermediate for the human picornavirus CAV16, revealing a major capsid protein partly extruded from the capsid and suggesting a model for RNA release.

    • Jingshan Ren
    • Xiangxi Wang
    • Elizabeth E. Fry
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-7

  • Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children, but no vaccine or antiviral therapy is available. Structural analysis of the mature virus and natural empty particles reveals that the larger empty particles resemble elusive enterovirus uncoating intermediates, allowing insight into the process of enterovirus uncoating.

    • Xiangxi Wang
    • Wei Peng
    • Zihe Rao
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 424-429

  • Understanding the stability of the eye lens protein human gamma-D crystallin (HGD) is essential to developing tools to prevent the formation of cataracts, however, structural investigations of the response of HGD to ultraviolet radiation are lacking. Here, the authors use continuous illumination serial crystallography to directly probe the mechanism of R36S HGD in response to ultraviolet radiation damage.

    • Jake A. Hill
    • Yvonne Nyathi
    • Briony A. Yorke
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-8