Cells secrete micro-RNAs by packaging them into exosomes; however, the mechanisms by which this packaging occurs are unclear. Here, the authors identify a sequence motif that confers exosomal targeting to micro-RNAs and identify a ribonucleoprotein complex that plays a role in this process.
- Carolina Villarroya-Beltri
- Cristina Gutiérrez-Vázquez
- Francisco Sánchez-Madrid