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Showing 1–18 of 18 results
Advanced filters: Author: Daohua Jiang Clear advanced filters

  • SLCO2A1 is an important prostaglandin (PG) transporter that regulates inactivation and distribution of PG. Here, authors present the cryo-EM structures of human SLCO2A1 bound with PGE2, revealing the structural basis of PG recognition and transport.

    • Zhanyi Xia
    • Guangyuan Lu
    • Daohua Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Riboflavin is an essential vitamin for humans. Here, authors present cryo-EM structures of human riboflavin transporter RFVT2/RFVT3, revealing the structural basis for riboflavin transport and defining the determinant for pH-dependent activity of RFVT3.

    • Ke Wang
    • Huiwen Chen
    • Daohua Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Fan et al. report a potent and subtype-selective TRPV3 antagonist, Trpvicin, and reveal its binding sites and mode of action for TRPV3 inhibition via high-resolution cryogenic electron microscopy structures.

    • Junping Fan
    • Linghan Hu
    • Xiaoguang Lei
    Research
    Nature Chemical Biology
    Volume: 19, P: 81-90

  • Cryo-electron microscopy structures of human XPR1 in different bound forms reveal the structural basis for XPR1 gating and regulation by inositol polyphosphates.

    • Rui Yan
    • Huiwen Chen
    • Daohua Jiang
    Research
    Nature
    Volume: 633, P: 960-967

  • Inactivation is an intrinsic property of NaV channel, but the mechanism for slow inactivation is not fully understood. Here, authors show a NaVEh structure in a potential slow-inactivated state, elucidating structural basis for slow inactivation.

    • Huiwen Chen
    • Zhanyi Xia
    • Daohua Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Here the authors show structures of the vesicular acetylcholine transporter in its apo state and in complex with the substrate acetylcholine and the inhibitor vesamicol, providing insights into substrate recognition, proton coupling and conformational transition mechanisms.

    • Qiao Ma
    • Kunpeng Ma
    • Yan Zhao
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 818-827

  • Voltage-gated sodium channels mediate electrical signaling. Here, authors report the cryo-EM structure of NaVEh from the marine plant Emiliania huxleyi, revealing an unexpected mechanism of N-type fast inactivation.

    • Jiangtao Zhang
    • Yiqiang Shi
    • Daohua Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • In C. elegans, systemic RNAi is initiated by SID-1-mediated dsRNA internalization. Here the authors present cryo-EM structures of SID-1 homologs and the SID-1–dsRNA complex, elucidating the structural basis for dsRNA recognition and uptake by SID-1.

    • Jiangtao Zhang
    • Chunhua Zhan
    • Daohua Jiang
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1095-1104

  • The voltage-gated sodium channel NaV1.7 plays essential roles in pain sensation. The authors report cryo-EM structures of NaV1.7 in complexes with three pore blockers, elucidating distinct mechanisms of action of their modulation on NaV1.7.

    • Jiangtao Zhang
    • Yiqiang Shi
    • Daohua Jiang
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 1208-1216

  • Structures of human vesicular monoamine transporter 2 in complexes with serotonin and three clinical drugs provide insights into the structural basis for serotonin transport and inhibition of transporter activity by the drugs.

    • Di Wu
    • Qihao Chen
    • Daohua Jiang
    Research
    Nature
    Volume: 626, P: 427-434

  • The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a unique intermediate-activated state and explains why LqhIII slows inactivation of NaV channels but does not open them.

    • Daohua Jiang
    • Lige Tonggu
    • William A. Catterall
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • An approach for the design of protein pores is demonstrated by the computational design and subsequent experimental expression of both an ion-selective and a large transmembrane pore.

    • Chunfu Xu
    • Peilong Lu
    • David Baker
    Research
    Nature
    Volume: 585, P: 129-134

  • Voltage-gated sodium channels function as multiprotein signaling complexes. Here, authors show that the dispanin TMEM233 is essential for activity of stinging nettle toxins and that co-expression of TMEM233 modulates the gating properties of NaV1.7.

    • Sina Jami
    • Jennifer R. Deuis
    • Irina Vetter
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Crystal structures and molecular dynamics simulations of voltage-gated sodium channels containing mutations that cause hypokalaemic and normokalaemic periodic paralysis indicate the pathogenic mechanisms of these conditions and suggest a target for the design of potential therapeutic and symptomatic drugs.

    • Daohua Jiang
    • Tamer M. Gamal El-Din
    • William A. Catterall
    Research
    Nature
    Volume: 557, P: 590-594