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Multiomic characterization of RNA microenvironments by oligonucleotide-mediated proximity-interactome mapping

Oligonucleotide-mediated proximity-interactome MAPping (O-MAP) enables precise multiomic characterization of biomolecular interaction networks at target RNAs. Distinct O-MAP workflows reveal RNA-adjacent proteins, transcripts and genomic loci.

Ashley F. Tsue
Evan E. Kania
David M. Shechner
Research28 Oct 2024
Nature Methods

Volume: 21, P: 2058-2071

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Multiomic characterization of RNA microenvironments by oligonucleotide-mediated proximity-interactome mapping

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