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Showing 1–4 of 4 results

Advanced filters: Author: Dario Finazzi Clear advanced filters

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

Julie G. Donaldson
Dario Finazzi
Richard D. Klausner
Research26 Nov 1992
Nature

Volume: 360, P: 350-352
Disease modeling by efficient genome editing using a near PAM-less base editor in vivo

Base Editors are emerging as an innovative technology to introduce point mutations in complex genomes. Here the authors describe a near PAM-less base editor and its application in zebrafish to efficiently create disease models harbouring specific point mutations.

Marion Rosello
Malo Serafini
Filippo Del Bene
ResearchOpen Access15 Jun 2022
Nature Communications

Volume: 13, P: 1-13
Pantethine ameliorates dilated cardiomyopathy features in PPCS deficiency disorder in patients and cell line models

Zhang, Dorn, Gnutti et al. identify pathogenic PPCS variants in people with PPCS deficiency disorder. Cardiac cells exhibit impaired contractility and arrhythmias, which is partially rescued by pantethine treatment.

Fangfang Zhang
Tatjana Dorn
Arcangela Iuso
ResearchOpen Access31 Jul 2025
Communications Medicine

Volume: 5, P: 1-17
Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish

Deepak Khatri
Daniela Zizioli
Dario Finazzi
ResearchOpen Access28 Nov 2016
Scientific Reports

Volume: 6, P: 1-15