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Showing 1–5 of 5 results
Advanced filters: Author: Dario Mizrachi Clear advanced filters

  • The study of integral membrane proteins (IMPs) is hampered by yields and the difficulty in retaining activity once they have been solubilized. Here Mizrachi et al. develop a strategy for in vivoexpression and solubilization of IMPs in functionally relevant states by fusing them to truncated apolipoprotein A-I.

    • Dario Mizrachi
    • Yujie Chen
    • Matthew P. DeLisa
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Access to glycoenzymes for basic and applied research is limited by difficulties with their recombinant expression. Here, the authors describe a universal strategy for converting membrane-bound glycosyltransferases into water-soluble biocatalysts, which are expressed at high levels with retention of activity.

    • Thapakorn Jaroentomeechai
    • Yong Hyun Kwon
    • Matthew P. DeLisa
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • The Eucalyptus grandis genome has been sequenced, revealing the greatest number of tandem duplications of any plant genome sequenced so far, and the highest diversity of genes for specialized metabolites that act as chemical defence and provide unique pharmaceutical oils; genome sequencing of the sister species E. globulus and a set of inbred E. grandis tree genomes reveals dynamic genome evolution and hotspots of inbreeding depression.

    • Alexander A. Myburg
    • Dario Grattapaglia
    • Jeremy Schmutz
    ResearchOpen Access
    Nature
    Volume: 510, P: 356-362