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Showing 1–15 of 15 results
Advanced filters: Author: Darleen A Sandoval Clear advanced filters

  • A two-in-one drug that modulates neural pathways involved in appetite and reward might prove to be more effective and longer lasting than current weight-loss drugs on the market.

    • Tyler M. Cook
    • Darleen Sandoval
    News & Views
    Nature
    Volume: 629, P: 1011-1012

  • Sandoval and colleagues discuss emerging evidence for a role of the CNS in the regulation of glucose homeostasis and show that this regulation involves several neural circuits and mechanisms that also control energy balance. Disruption of these overlapping pathways may link the metabolic impairments that are associated with obesity and type 2 diabetes.

    • Bernadette E. Grayson
    • Randy J. Seeley
    • Darleen A. Sandoval
    Reviews
    Nature Reviews Neuroscience
    Volume: 14, P: 24-37

  • A recent study has shown that a single dose of fibroblast growth factor (FGF) 1 into the central nervous system (CNS) of various mouse and rat models of type 2 diabetes results in profound and exceptionally long-lasting reductions in blood glucose. This work raises the possibility of truly revolutionary therapies for individuals with type 2 diabetes that target the brain FGF system.

    • Randy J Seeley
    • Darleen A Sandoval
    News & Views
    Nature Medicine
    Volume: 22, P: 709-711

  • Sleeve gastrectomy is a common bariatric surgery in which most of the gastric corpus is removed. Here, the authors show the adaptation of the gastric mucosa to surgery in patients, and how it facilitates maintenance of gastric pH homeostasis through a proportional-integral feedback control.

    • Amit Elad
    • Botros Moalem
    • Danny Ben-Zvi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • One effect of weight-loss surgery is a change in food preferences. An analysis in rats shows that this is caused by altered nutrient signals in the intestine. These activate the vagus nerve to increase signalling in the brain by the neurotransmitter dopamine.

    • Darleen A. Sandoval
    • Randy J. Seeley
    News & Views
    Nature
    Volume: 542, P: 302-303

  • Many people smoke to keep their weight down. The identification of the molecular target in the brain for the appetite-suppressant effects of nicotine is a first step towards finding healthy alternatives to smoking for weight management.

    • Randy J. Seeley
    • Darleen A. Sandoval
    News & Views
    Nature
    Volume: 475, P: 176-177

  • Coordination between peripheral signals that reflect feeding status and central regulatory mechanisms are crucial for regulating body weight. In this Review, Sandoval and colleagues discuss how and where peripherally derived signals are integrated within the CNS to modulate feeding behaviour.

    • Ki-Suk Kim
    • Randy J. Seeley
    • Darleen A. Sandoval
    Reviews
    Nature Reviews Neuroscience
    Volume: 19, P: 185-196

  • The authors of this Review integrate contributions of both central and peripheral glucagon-like peptide 1 (GLP-1), which is secreted from the intestine in response to nutrient ingestion, in a model of short-term and long-term control of energy balance. This model is discussed with respect to current GLP-1-based therapies and ongoing research that may help maximize the effectiveness of GLP-1-based treatment of obesity.

    • Jason G. Barrera
    • Darleen A. Sandoval
    • Randy J. Seeley
    Reviews
    Nature Reviews Endocrinology
    Volume: 7, P: 507-516

  • The growing appreciation of the regulatory role of the central nervous system (CNS) in energy and glucose homeostasis has the potential to lead to more effective long–term treatments for obesity and type 2 diabetes. Here, Sandoval and colleagues discuss the CNS pathways involved, identify promising therapeutic targets and strategies for diabetes and consider the associated challenges hampering the development of new agents.

    • Darleen A. Sandoval
    • Silvana Obici
    • Randy J. Seeley
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 386-398

  • Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are the most effective therapy for the treatment of obesity; now bile acids, and the presence of the nuclear bile acid receptor FXR, are shown to underpin the mechanism of VSG action, and the ability of VSG to reduce body weight and improve glucose tolerance is substantially reduced if FXR is absent.

    • Karen K. Ryan
    • Valentina Tremaroli
    • Randy J. Seeley
    Research
    Nature
    Volume: 509, P: 183-188

  • The mechanisms that mediate the effects of weight loss surgeries such as vertical sleeve gastrectomy (VSG) are incompletely understood. Here the authors show that intestinal FGF15 is necessary to improve glucose tolerance and to prevent the loss of muscle and bone mass after VSG, potentially via protection against bile acid toxicity.

    • Nadejda Bozadjieva-Kramer
    • Jae Hoon Shin
    • Randy J. Seeley
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Bariatric surgery induces weight loss and can trigger remission of type 2 diabetes mellitus (T2DM) but may also lead to post-bariatric hypoglycaemia. This Review examines surgery-induced changes in glucose regulation and the potential mechanisms responsible for the resolution of T2DM and induction of hypoglycaemia.

    • Darleen A. Sandoval
    • Mary Elizabeth Patti
    Reviews
    Nature Reviews Endocrinology
    Volume: 19, P: 164-176