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Showing 1–2 of 2 results
Advanced filters: Author: Darryl Aucoin Clear advanced filters

  • Amyloid-β42 (Aβ42) peptide aggregates to form oligomers, protofibrils and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's disease. Structural and functional analyses show that the conversion of Aβ42 oligomers to fibrils is accompanied by reduced neurotoxicity and involves the formation of parallel, in-register β-sheets that are staggered at an intermolecular contact.

    • Mahiuddin Ahmed
    • Judianne Davis
    • Steven O Smith
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 561-567

  • Prion diseases can be transmitted across species. Here the authors use solid-state NMR to study prion protein (PrP) amyloids from human, mouse and Syrian hamster and show that their structural differences are mainly governed by two residues, which helps to understand interspecies PrP propagation on a molecular level.

    • Theint Theint
    • Philippe S. Nadaud
    • Christopher P. Jaroniec
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10