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Showing 1–7 of 7 results

Advanced filters: Author: Dashyant Dhanak Clear advanced filters

Correction: Corrigendum: The promise and peril of chemical probes

Cheryl H Arrowsmith
James E Audia
William J Zuercher
Amendments and Corrections20 Oct 2015
Nature Chemical Biology

Volume: 11, P: 887
ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

Lusong Luo
Cynthia A Parrish
Kurt R Auger
Research07 Oct 2007
Nature Chemical Biology

Volume: 3, P: 722-726
Preclinical target validation using patient-derived cells

The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.

Aled M. Edwards
Cheryl H. Arrowsmith
L. Trevor Young
Comments & Opinion20 Feb 2015
Nature Reviews Drug Discovery

Volume: 14, P: 149-150
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

SMYD3 is a methyltransferase overexpressed in several human tumours; here methylation of the MAP3K2 kinase by SMYD3 is shown to be critical for Ras-induced tumour development in mouse models and human tumour cells, showing an unexpected role for methylation in a kinase signalling pathway and revealing a candidate therapeutic target.

Pawel K. Mazur
Nicolas Reynoird
Or Gozani
Research21 May 2014
Nature

Volume: 510, P: 283-287
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

EZH2 is a methyltransferase that is mutated in lymphoma; here a potent small molecule inhibitor of EZH2 is described, which inhibits the proliferation of EZH2 mutant cell lines and growth of EZH2 mutant xenografts in mice, thus providing a potential treatment for EZH2 mutant lymphoma.

Michael T. McCabe
Heidi M. Ott
Caretha L. Creasy
Research10 Oct 2012
Nature

Volume: 492, P: 108-112
Chromatin proteins and modifications as drug targets

Kristian Helin
Dashyant Dhanak
Reviews23 Oct 2013
Nature

Volume: 502, P: 480-488
The promise and peril of chemical probes

Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

Cheryl H Arrowsmith
James E Audia
William J Zuercher
Comments & Opinion21 Jul 2015
Nature Chemical Biology

Volume: 11, P: 536-541