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Showing 1–3 of 3 results
Advanced filters: Author: Dave Gennert Clear advanced filters

  • Single-cell RNA sequencing is used to investigate the transcriptional response of 18 mouse bone-marrow-derived dendritic cells after lipopolysaccharide stimulation; many highly expressed genes, such as key immune genes and cytokines, show bimodal variation in both transcript abundance and splicing patterns. This variation reflects differences in both cell state and usage of an interferon-driven pathway involving Stat2 and Irf7.

    • Alex K. Shalek
    • Rahul Satija
    • Aviv Regev
    Research
    Nature
    Volume: 498, P: 236-240