Nature Search

Hominin glacial-stage occupation 712,000 to 424,000 years ago at Fordwich Pit, Old Park (Canterbury, UK)

The authors report Acheulean hominin occupation of eastern Britain during glacial marine isotope stages 17–16 and again in glacial marine isotope stage 12 via stone tools in sediments dated to 712,000 to 424,000 years ago.

Alastair Key
James Clark
Tomos Proffitt
ResearchOpen Access01 Sept 2025
Nature Ecology & Evolution

Volume: 9, P: 1781-1790
Spliceosomal RNA U6 is remarkably conserved from yeast to mammals

David A. Brow
Christine Guthrie
Research21 Jul 1988
Nature

Volume: 334, P: 213-218
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Humans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) influencing nose morphology.

Kaustubh Adhikari
Macarena Fuentes-Guajardo
Andrés Ruiz-Linares
ResearchOpen Access19 May 2016
Nature Communications

Volume: 7, P: 1-11
A new hominid from the Upper Miocene of Chad, Central Africa

Michel Brunet
Franck Guy
Christoph Zollikofer
Research11 Jul 2002
Nature

Volume: 418, P: 145-151
Splicing a spliceosomal RNA

David A. Brow
Christine Guthrie
News & Views05 Jan 1989
Nature

Volume: 337, P: 14-15
Periorbital necrotising fasciitis

Geoffrey E Rose
David J Howard
Mark R Watts
Research01 Nov 1991
Eye

Volume: 5, P: 736-740
Enzymatic Debranching of Glycogen: Combined Action of Oligo-1,4→1,4-glucan-transferase and Amylo-1,6-glucosidase in Debranching Glycogen

DAVID H. BROWN
BARBARA ILLINGWORTH
CARL F. CORI
Research09 Mar 1963
Nature

Volume: 197, P: 980-982
Evidence from Tinshemet Cave in Israel suggests behavioural uniformity across Homo groups in the Levantine mid-Middle Palaeolithic circa 130,000–80,000 years ago

The Middle Palaeolithic of southwest Asia witnessed interactions and knowledge sharing between archaic and modern humans ~130,000–80,000 years ago. These interactions led to increased behavioural complexity and consolidation of a uniform behavioural set across Homo groups in the region.

Yossi Zaidner
Marion Prévost
Israel Hershkovitz
ResearchOpen Access11 Mar 2025
Nature Human Behaviour

Volume: 9, P: 886-901
Association of mutations in FLNA with craniosynostosis

Nathalie Fennell
Nicola Foulds
Andrew OM Wilkie
Research15 Apr 2015
European Journal of Human Genetics

Volume: 23, P: 1684-1688
Second gorilla or third chimp?

David Dean
Eric Delson
News & Views22 Oct 1992
Nature

Volume: 359, P: 676-677
A synergistic mindsets intervention protects adolescents from stress

An online training module that synergistically targets two different mindsets can reduce stress levels in adolescents in the context of social-evaluative stressors—stressful experiences in which individuals fear that others are judging them negatively.

David S. Yeager
Christopher J. Bryan
Jeremy P. Jamieson
ResearchOpen Access06 Jul 2022
Nature

Volume: 607, P: 512-520
Destruction of Young Fish

DAVID WILSON-BARKER
Research13 Oct 1887
Nature

Volume: 36, P: 557
Mitogenic Effect of Phytohaemagglutinin at Different Ages

ANTHONY V. PISCIOTTA
DAVID W. WESTRING
BRIAN WALSH
Research08 Jul 1967
Nature

Volume: 215, P: 193-194
Structure of the Earth's inner core

David R. Fearn
David E. Loper
Paul H. Roberts
Research01 Jul 1981
Nature

Volume: 292, P: 232-233
Academy slams Internet arts and sciences lookalike

David Adam
News14 Nov 2002
Nature

Volume: 420, P: 112
Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder

The identification of candidate neural biomarkers of obsessive-compulsive disorder symptom intensity in ecologically valid environments.

Nicole R. Provenza
Sameer A. Sheth
David A. Borton
Research09 Dec 2021
Nature Medicine

Volume: 27, P: 2154-2164
Absence of Vibration in a Turbine Steamship

DAVID TODD
Research19 Oct 1905
Nature

Volume: 72, P: 603-604
Simultaneous functional MRI of two awake marmosets

Here, the authors present MRI hardware and an image-processing pipeline for simultaneous functional imaging of two marmosets within the same scanner, removing the confounds of remote hyperscanning.

Kyle M. Gilbert
Justine C. Cléry
Stefan Everling
ResearchOpen Access16 Nov 2021
Nature Communications

Volume: 12, P: 1-11
Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

Daniel R. Knighton
Chen-Chen Kan
David A. Matthews
Research01 Mar 1994
Nature Structural Biology

Volume: 1, P: 186-194
Portable art from Pleistocene Sulawesi

Small, portable artworks have been missing from the archaeological record of the earliest Homo sapiens of Southeast Asia–Australasia. New excavations in Sulawesi have uncovered stone engravings of the natural world dating back to 26–14 ka.

Michelle C. Langley
Budianto Hakim
Adam Brumm
Research16 Mar 2020
Nature Human Behaviour

Volume: 4, P: 597-602
Appearance of Hipparion in the Tertiary of the Siwalik Hills of North India, Kashmir and West Pakistan

ELWYN L. SIMONS
DAVID PILBEAM
S. J. BOYER
Research05 Feb 1971
Nature

Volume: 229, P: 408-409
Alive with DEAD proteins

David A. Wassarman
Joan A. Steitz
News & Views07 Feb 1991
Nature

Volume: 349, P: 463-464
The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome

Laura Crisponi
Manila Deiana
Giuseppe Pilia
Research01 Feb 2001
Nature Genetics

Volume: 27, P: 159-166
Lateral canthotomy orbitotomy: a rapid approach to the orbit

S Hamed-Azzam
D H Verity
G E Rose
Research01 Sept 2017
Eye

Volume: 32, P: 333-337
New spinosaurids from the Wessex Formation (Early Cretaceous, UK) and the European origins of Spinosauridae

Chris T. Barker
David W. E. Hone
Neil J. Gostling
ResearchOpen Access29 Sept 2021
Scientific Reports

Volume: 11, P: 1-15
The cloning of GABA_B receptors

Norman G. Bowery
David A. Brown
News & Views20 Mar 1997
Nature

Volume: 386, P: 223-224
Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities

The mechanism of U6 small nuclear ribonucleoprotein (snRNP) biogenesis is not well understood. Here the authors characterize the enzymatic activities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcriptional assembly of yeast U6 snRNP in vitro, and propose a model for U6 snRNP assembly.

Allison L. Didychuk
Eric J. Montemayor
Samuel E. Butcher
ResearchOpen Access08 Sept 2017
Nature Communications

Volume: 8, P: 1-13
RNA-binding protein Nrd1 directs poly(A)-independent 3′-end formation of RNA polymerase II transcripts

Eric J. Steinmetz
Nicholas K. Conrad
Jeffry L. Corden
Research20 Sept 2001
Nature

Volume: 413, P: 327-331
8p23.1 duplication syndrome; a novel genomic condition with unexpected complexity revealed by array CGH

John C K Barber
Viv K Maloney
Emma Hobson
Research17 Oct 2007
European Journal of Human Genetics

Volume: 16, P: 18-27
Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure

Anna Huppler
Laura J. Nikstad
Samuel E. Butcher
Research06 May 2002
Nature Structural Biology

Volume: 9, P: 431-435
Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution

During spliceosome assembly, U6 snRNA is recycled from U2 snRNA by the protein Prp24 and is paired with U4 snRNA to form a splicing-competent complex. A structure of yeast Prp24 bound to the conserved core of U6 RNA reveals a new arrangement of RNA-protein contacts that mediates these early events leading to pre-mRNA splicing.

Eric J Montemayor
Elizabeth C Curran
David A Brow
Research18 May 2014
Nature Structural & Molecular Biology

Volume: 21, P: 544-551
Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA

The spliceosome removes introns from precursor messenger RNAs to produce mature mRNAs. Here the authors report a U6 snRNP crystal structure that provides insight on how the 3′ phosphate of U6 snRNA is recognized by the Lsm2–8 complex and how the U6 snRNP proteins sequester and protect the active site RNA until it is assembled into the spliceosome.

Eric J. Montemayor
Allison L. Didychuk
Samuel E. Butcher
ResearchOpen Access01 May 2018
Nature Communications

Volume: 9, P: 1-11
Detection of chromosomal aneuploidy in ancient genomes

A sex chromosome identification method for ancient DNA revealed six individuals who lived with chromosomal aneuploidies in Britain from ~ 2,500 to 250 years ago. Genomic and osteological information was combined to shed light on their lives.

Kyriaki Anastasiadou
Marina Silva
Pontus Skoglund
ResearchOpen Access11 Jan 2024
Communications Biology

Volume: 7, P: 1-9
Lifeboat

A family adrift.

David Carr
Comments & Opinion25 Jul 2012
Nature

Volume: 487, P: 524
Both partners’ negative emotion drives aggression during couples’ conflict

Couples competing in a reaction time task where they can play loud sounds to their partner are more aggressive when negative facial affect is expressed. Couples retaliate, but introducing short breaks reduces negative affect and aggressive behaviour.

Annah G. McCurry
Robert C. May
David I. Donaldson
ResearchOpen Access07 Aug 2024
Communications Psychology

Volume: 2, P: 1-16
Eye on RNA unwinding

Biochemical studies on the spliceosomal helicase Brr2 reveal that it is activated by Prp8, the master regulator of the splicing cycle. Substitutions in Prp8 that cause retinal degeneration in humans block activation of Brr2, providing insight into the molecular pathology of retinitis pigmentosa.

David A Brow
News & Views01 Jan 2009
Nature Structural & Molecular Biology

Volume: 16, P: 7-8
Single-molecule analysis of protein-free U2–U6 snRNAs

The U2–U6 snRNA complex is argued to adopt different conformations during splicing. Using single-molecule FRET, the dynamics of an RNA representing U2–U6 are now probed and related to splicing steps through probing of mutations previously linked to this process.

Zhuojun Guo
Krishanthi S Karunatilaka
David Rueda
Research01 Nov 2009
Nature Structural & Molecular Biology

Volume: 16, P: 1154-1159
Craniosynostosis

David Johnson
Andrew O M Wilkie
Research19 Jan 2011
European Journal of Human Genetics

Volume: 19, P: 369-376
Application and demonstration of meso-activity exposure factors to advance estimates of incidental soil ingestion among agricultural workers

Sara N. Lupolt
Brent F. Kim
Keeve E. Nachman
ResearchOpen Access17 May 2024
Journal of Exposure Science & Environmental Epidemiology

Volume: 35, P: 303-314
Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes

Victor Lyamichev
Andrea L. Mast
Mary Ann D. Brow
Research01 Mar 1999
Nature Biotechnology

Volume: 17, P: 292-296
Transcervical artificial insemination in the brown brocket deer (Subulo gouazoubira): a promising method for assisted reproduction in deer

Gabriella Saloni Duarte
David Javier Galindo
Maria Emilia Franco Oliveira
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
De novo and inherited variants in ZNF292 underlie a neurodevelopmental disorder with features of autism spectrum disorder

Ghayda M. Mirzaa
Jessica X. Chong
Michael J. Bamshad
Research14 Nov 2019
Genetics in Medicine

Volume: 22, P: 538-546
Computer-aided diagnostic screen for Congenital Central Hypoventilation Syndrome with facial phenotype

Susan M. Slattery
James Wilkinson
Debra E. Weese-Mayer
Research18 Jan 2024
Pediatric Research

Volume: 95, P: 1843-1850
The Oldest Highlands of Mars May Be Massive Dust Fallout Deposits

J. Alexis P. Rodriguez
Eldar Noe Dobrea
Denise Buckner
ResearchOpen Access25 Jun 2020
Scientific Reports

Volume: 10, P: 1-15
SMAD6 variants in craniosynostosis: genotype and phenotype evaluation

Eduardo Calpena
Araceli Cuellar
Andrew O. M. Wilkie
ResearchOpen Access05 Jun 2020
Genetics in Medicine

Volume: 22, P: 1498-1506
Women’s preferences for men’s facial masculinity are strongest under favorable ecological conditions

Urszula M. Marcinkowska
Markus J. Rantala
Barnaby J. W. Dixson
ResearchOpen Access04 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
A PtdIns4,5P₂-regulated nuclear poly(A) polymerase controls expression of select mRNAs

A new polyadenylation polymerase, called Star-PAP, is identified, the activity of which is regulated by nuclear phosphoinositides generated by the kinase PIPKIα.

David L. Mellman
Michael L. Gonzales
Richard A. Anderson
Research21 Feb 2008
Nature

Volume: 451, P: 1013-1017
Novel Expression of Chimeric Plasminogen Activators in Insect Cells

James J. Devlin
Patricia E. Devlin
David F. Mark
Research01 Mar 1989
Bio/Technology

Volume: 7, P: 286-292
‘Stalled’ periocular necrotising fasciitis: early effective treatment or host genetic determinants?

A Mutamba
D H Verity
G E Rose
Research15 Feb 2013
Eye

Volume: 27, P: 432-437
Development of an in vitro model of myotube ischemia

Dhiraj Joshi
Hemanshu Patel
Janice C Tsui
Research23 May 2011
Laboratory Investigation

Volume: 91, P: 1241-1252

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