Lipids can modulate amyloid-β aggregation, yet the combined effects of lipids in heterogeneous membranes remain unclear. Here, the authors reveal that ganglioside GM1 inhibits amyloid-β aggregation by sequestering soluble Aβ(1-42) and retards primary nucleation, with cholesterol and sphingomyelin modulating this effect, highlighting the mechanism of membrane-mediated Aβ(1-42) aggregation.
- Nima Sasanian
- Vesa Halipi
- Elin K. Esbjörner
