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Showing 1–11 of 11 results
Advanced filters: Author: David C. Tscharke Clear advanced filters

  • Data collected from more than 2,000 taxa provide an unparalleled opportunity to quantify how extreme wildfires affect biodiversity, revealing that the largest effects on plants and animals were in areas with frequent or recent past fires and within extensively burnt areas.

    • Don A. Driscoll
    • Kristina J. Macdonald
    • Ryan D. Phillips
    ResearchOpen Access
    Nature
    Volume: 635, P: 898-905

  • CTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell responses in infected mice.

    • Ting Wu
    • Jing Guan
    • Nicole L. La Gruta
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lytic pore formation.

    • Daniel Fox
    • Anukriti Mathur
    • Si Ming Man
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Long-lived tissue-resident memory T cells (TRM cells) confer fast, robust protection after pathogen rechallenge. Gebhardt and colleagues show that skin TRM cells arise from KLRG1– cells that differentiate in situ in response to IL-15 and TGF-β.

    • Laura K Mackay
    • Azad Rahimpour
    • Thomas Gebhardt
    Research
    Nature Immunology
    Volume: 14, P: 1294-1301

  • T cells are recruited into the battle against pathogens by interaction with professional antigen-presenting cells (APCs). A new study shows that this recruitment phase is short and terminates when newly activated T cells kill the activating APCs.

    • David C Tscharke
    • Jonathan W Yewdell
    News & Views
    Nature Medicine
    Volume: 9, P: 647-648

  • Here, the authors explain how the specificity and magnitude of the primary cytotoxic T lymphocyte (CTL) response is determined during a viral infection. They discuss the different factors that influence the recruitment and expansion of naive CTL precursors, and they explain how technological advances have enabled a more accurate quantitation of these responses.

    • David C. Tscharke
    • Nathan P. Croft
    • Nicole L. La Gruta
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 705-716

  • Real-time microscopy is providing fresh insights in many fields of biology. Immunology is no exception, as demonstrated by striking images of the inner workings of dendritic cells.

    • Jonathan W. Yewdell
    • David C. Tscharke
    News & Views
    Nature
    Volume: 418, P: 923-924

  • Gowripalan, Smith et al. use CRISPR/Cas9 technology to rapidly select recombinant poxviruses without using selectable marker genes. They find that Cas9 cleavage inhibits poxvirus DNA replication, suppressing virus spread in culture. This application makes poxviruses more attractive vector platforms for fighting cancer and emerging disease outbreaks.

    • Anjali Gowripalan
    • Stewart Smith
    • David C. Tscharke
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13