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Showing 1–10 of 10 results
Advanced filters: Author: David Chetrit Clear advanced filters

  • SpatialGlue is a graph neural network-based approach for integrating multimodal spatial omics data. Combining complementary data modalities improves the discovery of spatial domains as well as the identification of cell subpopulations across tissues.

    • Yahui Long
    • Kok Siong Ang
    • Jinmiao Chen
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1658-1667

  • From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

    • Cristina Taddei
    • Bin Zhou
    • Majid Ezzati
    ResearchOpen Access
    Nature
    Volume: 582, P: 73-77

  • A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion mechanisms.

    • Amit Meir
    • Kevin Macé
    • Gabriel Waksman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Inhibitors of poly(ADP-ribose)polymerase (PARP) have shown promise as therapeutic agents for the treatment of ovarian cancers with mutations inBRCA1 or BRCA2. By exploiting the synthetic lethal interaction that exists between PARP inhibition and BRCA mutations, these agents specifically kill cancer cells by targeting their DNA repair system. The authors of this Review describe the importance of BRCAmutations for the efficacy of PARP inhibitors. They also discuss the preclinical and clinical trial results of PARP inhibitors, the challenges related to the use of these agents, and future directions.

    • Susana Banerjee
    • Stan B. Kaye
    • Alan Ashworth
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 7, P: 508-519

  • Legionella pneumophila employs the Type 4B secretion system (T4BSS) to translocate more than 300 effector proteins into the host cell during infection. Here the authors present the crystal structure of the DotM soluble domain and give mechanistic insights into the recruitment of Glu-rich motif-containing effectors to the T4BSS.

    • Amit Meir
    • David Chetrit
    • Gabriel Waksman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12