Nature Search

Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic

Broad-spectrum vaccines have been proposed as a tool for rapid response to emerging infectious disease threats and are in pre-clinical development. Here, the authors use mathematical modelling to assess the potential impacts of broadly protective sarbecovirus vaccines for a hypothetical “SARS-X” outbreak.

Charles Whittaker
Gregory Barnsley
Azra C. Ghani
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-12
Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

Haruo Saito
David M. Kranz
Susumu Tonegawa
Research28 Jun 1984
Nature

Volume: 309, P: 757-762
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
SARS-CoV-2 Omicron variant emerged under immune selection

Comprenhensive analysis of human antibody responses to SARS-CoV-2 variants and animal sarbecoviruses finds that Omicron escapes neutralization more readily than distantly related animal sarbecoviruses.

Chee Wah Tan
Wan Ni Chia
Lin-Fa Wang
Research04 Oct 2022
Nature Microbiology

Volume: 7, P: 1756-1761
Hyperlipidemia, statin use and dengue severity

Po Ying Chia
Htet Lin Htun
David Chien Boon Lye
ResearchOpen Access21 Nov 2018
Scientific Reports

Volume: 8, P: 1-7
Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients

Here, the authors sample air and surfaces in hospital rooms of COVID-19 patients, detect SARS-CoV-2 RNA in air samples of two of three tested airborne infection isolation rooms, and find surface contamination in 66.7% of tested rooms during the first week of illness and 20% beyond the first week of illness.

Po Ying Chia
Kristen Kelli Coleman
Daniela Moses
ResearchOpen Access29 May 2020
Nature Communications

Volume: 11, P: 1-7
NK cells are activated and primed for skin-homing during acute dengue virus infection in humans

Here, Zimmer et al. analyze the natural killer (NK) cell response in a patient cohort with acute dengue virus infection showing early NK cell activation and proliferation, and the data suggest that NK cell proliferation depends on IL-18 signaling, and that responding NK cells have a skin-homing phenotype.

Christine L. Zimmer
Martin Cornillet
Niklas K. Björkström
ResearchOpen Access29 Aug 2019
Nature Communications

Volume: 10, P: 1-15
Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19.

Guillaume Carissimo
Weili Xu
Lisa FP Ng
ResearchOpen Access16 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Differentiating coronavirus disease 2019 (COVID-19) from influenza and dengue

Tun-Linn Thein
Li Wei Ang
David Chien Boon Lye
ResearchOpen Access05 Oct 2021
Scientific Reports

Volume: 11, P: 1-9
Statin use is associated with lower disease severity in COVID-19 infection

Wilnard Y. T. Tan
Barnaby E. Young
Rinkoo Dalan
ResearchOpen Access15 Oct 2020
Scientific Reports

Volume: 10, P: 1-7
Age- and vaccination status-dependent isolation guidelines based on simulation of SARS-CoV-2 Delta cases in Singapore

Ejima et al. introduce a computational protocol to evaluate isolation guidelines, showing that adjusting isolation durations based on age and vaccination status reduces unnecessary isolation by 1.4 to 1.8 days per person while maintaining safety. Tailored isolation periods minimize redundant isolation and mitigate transmission risks.

Keisuke Ejima
Marco Ajelli
Barnaby E. Young
ResearchOpen Access13 Mar 2025
Communications Medicine

Volume: 5, P: 1-9
Author Correction: Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity

Tommy Hing-Cheung Tang
Sylvie Alonso
Tsin-Wen Yeo
Amendments and CorrectionsOpen Access21 Jun 2021
Scientific Reports

Volume: 11, P: 1
Myeloperoxidase inhibition may protect against endothelial glycocalyx shedding induced by COVID-19 plasma

Teo et al. study neutrophil activity and endothelial glycocalyx damage in plasma collected from healthy individuals and patients with severe and non-severe COVID-19. They show that neutrophil myeloperoxidase activity and endothelial glycocalyx proteins increase with disease severity, and remain high despite clinical recovery.

Andrew Teo
Louisa L. Y. Chan
Tsin Wen Yeo
ResearchOpen Access05 May 2023
Communications Medicine

Volume: 3, P: 1-9
Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity

Tommy Hing-Cheung Tang
Sylvie Alonso
Tsin-Wen Yeo
ResearchOpen Access10 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore

Ser Hon Puah
Barnaby Edward Young
Gabriel Zherong Yan
ResearchOpen Access05 Apr 2021
Scientific Reports

Volume: 11, P: 1-11

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