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Showing 1–9 of 9 results
Advanced filters: Author: David Dominguez-Sola Clear advanced filters

  • Heeger and colleagues report that activated B cells dynamically regulate the expression of complement regulatory proteins via the transcription factor BCL6. C3 convertase activity and C3aR1–C5aR1 signaling were both necessary for optimal B cell activation and germinal center formation.

    • Arun Cumpelik
    • David Heja
    • Peter S. Heeger
    Research
    Nature Immunology
    Volume: 22, P: 757-768

  • A new, transcription-independent function for c-Myc is identified. It is found that c-Myc can bind factors involved in DNA replication, thereby causing DNA damage and affecting cell proliferation. This process may also contribute to oncogenesis.

    • David Dominguez-Sola
    • Carol Y. Ying
    • Riccardo Dalla-Favera
    Research
    Nature
    Volume: 448, P: 445-451

  • Two studies demonstrate that the methyltransferase KMT2D, which is recurrently mutated in several types of human B cell lymphoma, suppresses tumorigenesis by altering the epigenetic landscape of B cells; Kmt2d deletion in mice perturbs normal B cell development.

    • Jiyuan Zhang
    • David Dominguez-Sola
    • Laura Pasqualucci
    Research
    Nature Medicine
    Volume: 21, P: 1190-1198

  • The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.

    • Slim Mzoughi
    • Jia Yi Fong
    • Ernesto Guccione
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • In three different subtypes of B-cell lymphomas, two papers now report frequent somatic mutations in CREBBP and EP300, present in primary tumours or acquired at relapse. These genes encode related acetyltransferases that mainly function to regulate gene expression by acetylating histones and other transcriptional regulators. The mutations found inactivate these activities and thus alter chromatin regulation of gene expression, as well as proliferation and potentially the response to therapeutic drugs.

    • Laura Pasqualucci
    • David Dominguez-Sola
    • Riccardo Dalla-Favera
    Research
    Nature
    Volume: 471, P: 189-195

  • The proto-oncogenic transcription factor c-Myc is a central regulator of the cell cycle and cell growth. Amino-terminal phosphorylation of c-Myc results in its proteasomal degradation. A new study shows that its dephosphorylation is regulated by the Pin1 prolyl isomerase and PP2A phosphatase, and that stabilized c-Myc can replace SV40 small T antigen in the oncogenic transformation of human cells.

    • David Dominguez-Sola
    • Riccardo Dalla-Favera
    News & Views
    Nature Cell Biology
    Volume: 6, P: 288-289