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Showing 1–5 of 5 results
Advanced filters: Author: David E. Clemmer Clear advanced filters

    • David Jones
    News & Views
    Nature
    Volume: 370, P: 602

  • The size and shape of amyloid-β protein assemblies have been studied using electrospray-ionization ion-mobility mass spectrometry, and the protein tetramers and dodecamers have been identified as an important oligomerization state in the development of neurodegenerative disease.

    • David E. Clemmer
    • Stephen J. Valentine
    News & Views
    Nature Chemistry
    Volume: 1, P: 257-258

  • Transcription factor p53 is sensitive and selective to a broad variety of cellular environments, with oxidative stress demonstrated to weaken p53-DNA binding for certain promoters, but the precise mechanisms by which the physiologically relevant DNA-p53 tetramer complex senses cellular stresses caused by H2O2 remain unknown. Here, native mass spectrometry and ion mobility–mass spectrometry are coupled with chemical labelling and H2O2-induced oxidation to probe the mechanism of redox regulation of the p53-p21 complex.

    • Manuel David Peris-Díaz
    • Artur Krężel
    • Perdita Barran
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-14