Nature Search

Genetic insights into resting heart rate and its role in cardiovascular disease

The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke.

Yordi J. van de Vegte
Ruben N. Eppinga
Pim van der Harst
ResearchOpen Access02 Aug 2023
Nature Communications

Volume: 14, P: 1-21
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

Damian Smedley and colleagues report the phenotypic characterization of the first 3,328 genes by the International Mouse Phenotyping Consortium. They develop new mouse models based on genes known to be associated with human mendelian diseases and identify potential disease-associated genes with little or no previous functional annotation.

Terrence F Meehan
Nathalie Conte
Damian Smedley
Research26 Jun 2017
Nature Genetics

Volume: 49, P: 1231-1238
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

Tuomas O. Kilpeläinen
Amy R. Bentley
Ruth J. F. Loos
ResearchOpen Access22 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.

Ioanna Ntalla
Lu-Chen Weng
Patricia B. Munroe
ResearchOpen Access21 May 2020
Nature Communications

Volume: 11, P: 1-12
Genetics in Allergy: A Model for Studying the Genetics of Human Immune Responsiveness

David G Marsh
Research01 Oct 1986
Pediatric Research

Volume: 20, P: 1032-1033
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Several β-secretase (BACE) inhibitors exhibit unexplained ocular toxicity in preclinical studies. Here the authors generate a clickable photoaffinity probe to interrogate off-targets in cells and animals, and identify inhibition of cathepsin D as a driver of ocular toxicity.

Andrea M. Zuhl
Charles E. Nolan
Douglas S. Johnson
ResearchOpen Access11 Oct 2016
Nature Communications

Volume: 7, P: 1-14
Structural basis of the acyl-transfer mechanism of human GPAT1

GPAT1 is a mitochondrial outer membrane protein that catalyzes the first step of glycerolipid biosynthesis. Cryo-EM structures and functional studies of human GPAT1 uncover the molecular architecture and mechanism of this important acyltransferase.

Zachary Lee Johnson
Mark Ammirati
Huixian Wu
Research15 Dec 2022
Nature Structural & Molecular Biology

Volume: 30, P: 22-30
The effect of various bulk filling techniques on the mechanical and structural characteristics of class I biomimetic composite dental fillings

Alexandra Kemény
Péter Zoltán Farkas
Balázs Varbai
ResearchOpen Access05 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Spontaneous Variability in Minute Ventilation Oxygen Consumption and Heart Rate of Low Birth Weight Infants

Karl Schulze
Ram Kairam
L S James
Research01 Aug 1981
Pediatric Research

Volume: 15, P: 1111-1116
An African origin for the intimate association between humans and Helicobacter pylori

As is the case with humans, Helicobacter pylori shows genetic evidence of an origin in Africa and subsequent migrations to the rest of the world.

Bodo Linz
François Balloux
Mark Achtman
Research07 Feb 2007
Nature

Volume: 445, P: 915-918
Genome-wide meta-analysis identifies new susceptibility loci for migraine

Verneri Anttila and colleagues report meta-analysis of 29 genome-wide association studies for migraine. They identify five loci newly associated with migraine, three of which are associated with specific subtypes of migraine with or without aura.

Verneri Anttila
Bendik S Winsvold
Aarno Palotie
Research23 Jun 2013
Nature Genetics

Volume: 45, P: 912-917
Endoscopic enucleation of the prostate versus transurethral resection of the prostate for benign prostatic hyperplasia: a systematic review and meta-analysis

Lequang T. Vo
David Armany
Henry H. Woo
ReviewsOpen Access10 May 2025
Prostate Cancer and Prostatic Diseases

P: 1-14
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Lisa de las Fuentes
Yun Ju Sung
Myriam Fornage
Research05 May 2020
Molecular Psychiatry

Volume: 26, P: 2111-2125
Autosomal recessive Noonan syndrome associated with biallelic LZTR1 variants

Jennifer J Johnston
Jasper J van der Smagt
Leslie G Biesecker
Research22 Feb 2018
Genetics in Medicine

Volume: 20, P: 1175-1185
Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Xinzhu Wang
Ruud Nijman
Veslava Žukovskaja
ResearchOpen Access27 Nov 2019
Scientific Reports

Volume: 9, P: 1-13
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Lisa Borghini
Eileen Png
Peter Schermann
ResearchOpen Access06 May 2019
Scientific Reports

Volume: 9, P: 1-15
Paediatric ophthalmology in West Mostar, Bosnia

Mark Elder
David Southall
Correspondence01 Jan 1997
Eye

Volume: 11, P: 132-135
Comparison of ¹⁸F-based PSMA radiotracers with [⁶⁸Ga]Ga-PSMA-11 in PET/CT imaging of prostate cancer—a systematic review and meta-analysis

Siyu Huang
Sean Ong
Marlon Perera
ReviewsOpen Access28 Nov 2023
Prostate Cancer and Prostatic Diseases

Volume: 27, P: 654-664

Search

Genetic insights into resting heart rate and its role in cardiovascular disease

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Genetics in Allergy: A Model for Studying the Genetics of Human Immune Responsiveness

Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors

Structural basis of the acyl-transfer mechanism of human GPAT1

The effect of various bulk filling techniques on the mechanical and structural characteristics of class I biomimetic composite dental fillings

Spontaneous Variability in Minute Ventilation Oxygen Consumption and Heart Rate of Low Birth Weight Infants

An African origin for the intimate association between humans and Helicobacter pylori

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Endoscopic enucleation of the prostate versus transurethral resection of the prostate for benign prostatic hyperplasia: a systematic review and meta-analysis

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Autosomal recessive Noonan syndrome associated with biallelic LZTR1 variants

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Paediatric ophthalmology in West Mostar, Bosnia

Comparison of ¹⁸F-based PSMA radiotracers with [⁶⁸Ga]Ga-PSMA-11 in PET/CT imaging of prostate cancer—a systematic review and meta-analysis

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