Nature Search

A permanent window for the murine lung enables high-resolution imaging of cancer metastasis

The window for high-resolution imaging of the lung (WHRIL) enables longitudinal imaging of the same region of murine lung tissue over a period of weeks, and this enables the visualization of spontaneous cancer metastasis from the earliest stages.

David Entenberg
Sonia Voiculescu
John Condeelis
Research27 Nov 2017
Nature Methods

Volume: 15, P: 73-80
Correction: Corrigendum: Mechanism of early dissemination and metastasis in Her2⁺ mammary cancer

Kathryn L. Harper
Maria Soledad Sosa
Julio A. Aguirre-Ghiso
Amendments and Corrections13 Dec 2017
Nature

Volume: 553, P: 366
Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

Intravital imaging reveals macrophage-driven de novo induction of cancer stem cells in vivo, and their dramatic enrichment on dissemination through TMEM doorways. These findings provide a mechanism for the validated ability of TMEM doorway density to be prognostic for distant recurrence of metastatic tumors in breast cancer patients.

Ved P. Sharma
Binwu Tang
Maja H. Oktay
ResearchOpen Access15 Dec 2021
Nature Communications

Volume: 12, P: 1-24
Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells

The understanding of the mechanisms underlying the ability of disseminated tumor cells (DTCs) to form metastasis is incomplete. Here, by using high-resolution intravital imaging of the murine lung to track the fate of breast-derived DTCs, the authors show that macrophages within the primary tumor induce a pro-dissemination and pro-dormancy phenotype in tumor cells, favouring their extravasation in the lung.

Lucia Borriello
Anouchka Coste
David Entenberg
ResearchOpen Access02 Feb 2022
Nature Communications

Volume: 13, P: 1-19
In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging

Joseph M. Szulczewski
David R. Inman
Patricia J. Keely
ResearchOpen Access25 May 2016
Scientific Reports

Volume: 6, P: 1-9
Targeting CSF-1 signaling between tumor cells and macrophages at TMEM doorways inhibits breast cancer dissemination

Camille L. Duran
Chinmay R. Surve
John S. Condeelis
ResearchOpen Access11 Jul 2025
Oncogene

Volume: 44, P: 3297-3309
Brightness-equalized quantum dots

Quantum dots with different size emit light at different wavelengths but also different brightness, which complicates analysis of fluorescence images. Here, the authors synthesize multicolour brightness-equalized quantum dots by controlling the composition and structure of core-shell HgCdSeS-CdZnS nanocrystals.

Sung Jun Lim
Mohammad U. Zahid
Andrew M. Smith
ResearchOpen Access05 Oct 2015
Nature Communications

Volume: 6, P: 1-10
Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

Aguirre-Ghiso and colleagues report that hypoxia in the primary tumour microenvironment leads to upregulation of a dormancy signature in the tumour cells that persists after their dissemination to distant sites, permitting them to evade therapy.

Georg Fluegen
Alvaro Avivar-Valderas
Julio A. Aguirre-Ghiso
Research23 Jan 2017
Nature Cell Biology

Volume: 19, P: 120-132
Intravital imaging to study cancer progression and metastasis

This Review covers recent advances in intravital imaging of mammalian models of cancer and describes how intravital imaging can help to understand the role of the tumour microenvironment in cancer progression and metastasis, and to develop novel treatments and therapies.

David Entenberg
Maja H. Oktay
John S. Condeelis
Reviews16 Nov 2022
Nature Reviews Cancer

Volume: 23, P: 25-42
Multiphoton intravital microscopy of rodents

Intravital microscopy (IVM) techniques are used to visualize intact and live tissues at the cellular and subcellular level. In this Primer, Scheele, Herrmann et al. discuss IVM in rodents, outlining challenges and opportunities for using the technique.

Colinda L. G. J. Scheele
David Herrmann
Jacco van Rheenen
Reviews10 Nov 2022
Nature Reviews Methods Primers

Volume: 2, P: 1-26
Mechanism of early dissemination and metastasis in Her2⁺ mammary cancer

Two related papers show that cells disseminated from malignant lesions at early time points during tumorigenesis can contribute to metastases at distant organs and provide insights into the molecular basis of dissemination.

Kathryn L. Harper
Maria Soledad Sosa
Julio A. Aguirre-Ghiso
Research14 Dec 2016
Nature

Volume: 540, P: 588-592
In vivo imaging of labelled endogenous β-actin mRNA during nucleocytoplasmic transport

Newly synthesized messenger RNA is exported from the nucleus through nuclear pores. Here, a new imaging and tracking method has been developed to study the kinetics of mRNA export, with 20-ms time-precision and 26-nm spatial precision. A three-step model for export is presented, comprising docking, transport and release. Notably, mRNAs can move bi-directionally through the pore complex.

David Grünwald
Robert H. Singer
Research15 Sept 2010
Nature

Volume: 467, P: 604-607
Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy

Gina Kim
Burcu Karadal-Ferrena
Maja H. Oktay
ResearchOpen Access13 Jun 2023
npj Breast Cancer

Volume: 9, P: 1-11
Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy

George S. Karagiannis
Anthony Bianchi
John S. Condeelis
ResearchOpen Access02 Sept 2022
npj Breast Cancer

Volume: 8, P: 1-16
A metastasis biomarker (MetaSite Breast™ Score) is associated with distant recurrence in hormone receptor-positive, HER2-negative early-stage breast cancer

Joseph A. Sparano
Robert Gray
Joan Jones
ResearchOpen Access08 Nov 2017
npj Breast Cancer

Volume: 3, P: 1-8
Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging

David Entenberg
Jeffrey Wyckoff
John Condeelis
Protocols08 Sept 2011
Nature Protocols

Volume: 6, P: 1500-1520

Search

A permanent window for the murine lung enables high-resolution imaging of cancer metastasis

Correction: Corrigendum: Mechanism of early dissemination and metastasis in Her2⁺ mammary cancer

Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells

In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging

Targeting CSF-1 signaling between tumor cells and macrophages at TMEM doorways inhibits breast cancer dissemination

Brightness-equalized quantum dots

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

Intravital imaging to study cancer progression and metastasis

Multiphoton intravital microscopy of rodents

Mechanism of early dissemination and metastasis in Her2⁺ mammary cancer

In vivo imaging of labelled endogenous β-actin mRNA during nucleocytoplasmic transport

Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy

Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy

A metastasis biomarker (MetaSite Breast™ Score) is associated with distant recurrence in hormone receptor-positive, HER2-negative early-stage breast cancer

Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging

Search

Quick links

Search

Filter By:

Search

Quick links